Brain functional connectivity and cognition in mild traumatic brain injury

Introduction The aim of this study was to analyze brain functional connectivity and its relationship to cognition in patients with mild traumatic brain injury (mTBI). Methods Twenty-five patients with mTBI and 25 healthy control subjects were studied using resting-state functional MRI (rs-fMRI). Amp...

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Bibliographic Details
Published in:Neuroradiology 2016-07, Vol.58 (7), p.733-739
Main Authors: Xiong, K.L., Zhang, J.N., Zhang, Y.L., Zhang, Y., Chen, H., Qiu, M.G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain - diagnostic imaging
Brain - physiopathology
Brain damage
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - diagnostic imaging
Brain Injuries, Traumatic - physiopathology
Cognition
Cognition Disorders - diagnostic imaging
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Cognitive ability
Connectome - methods
Female
Functional Neuroradiology
Humans
Imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Nerve Net - diagnostic imaging
Nerve Net - physiopathology
Neurology
Neuroradiology
Neurosciences
Neurosurgery
NMR
Nuclear magnetic resonance
Radiology
Reproducibility of Results
Sensitivity and Specificity
Young Adult
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Summary:Introduction The aim of this study was to analyze brain functional connectivity and its relationship to cognition in patients with mild traumatic brain injury (mTBI). Methods Twenty-five patients with mTBI and 25 healthy control subjects were studied using resting-state functional MRI (rs-fMRI). Amplitudes of low-frequency fluctuations (ALFFs) and functional connectivity (FC) were calculated and correlated with cognition. Results Compared with the normal control group, the mTBI patients showed a significant decrease in working memory index (WMI) and processing speed index (PSI), as well as significantly decreased ALFFs in the cingulate gyrus, the middle frontal gyrus and superior frontal gyrus. In contrast, the mTBI patients’ ALFFs in the left middle occipital gyrus, the left precuneus, and lingual gyrus increased. Additionally, FC significantly decreased in the thalamus, caudate nucleus, and right hippocampus in the mTBI patients. Statistical analysis further showed a significant positive correlation between the ALFF in the cingulate gyrus and the WMI ( R 2  = 0.423, P  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-016-1675-0