Template-Directed Synthesis of Porous and Protective Core-Shell Bionanoparticles

Metal–organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as‐prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2016-08, Vol.55 (36), p.10691-10696
Main Authors: Li, Shaobo, Dharmarwardana, Madushani, Welch, Raymond P., Ren, Yixin, Thompson, Christina M., Smaldone, Ronald A., Gassensmith, Jeremiah J.
Format: Article
Language:English
Subjects:
bioconjugation reactions
Composite materials
Coordination polymers
Hybrids
Metal-organic frameworks
Metals
nanoparticles
Polymers
Robustness
Shell stability
Surface area
Tobacco
tobacco mosaic virus
Transportation
Variability
Viruses
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Summary:Metal–organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as‐prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as‐fabricated MOF materials. We were able to obtain discrete rod‐shaped TMV@MOF core–shell hybrids with good uniformity, and their diameters could be tuned by adjusting the synthetic conditions, which can also significantly impact the stability of the core–shell composite. More interestingly, the virus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell. It's a wrap: Sleeve netting provides a cost‐effective solution to keep fresh fruits safe and sound. A metal–organic framework (MOF) is used to construct a molecular protective netting on the surface of the rod‐like tobacco mosaic virus. The shell thickness was discovered to play a crucial role in the stability of the core–shell composite. More interestingly, the embedded virus particle can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201604879