Epilepsy‐associated tumours: what epileptologists should know about neuropathology, terminology, and classification systems

Brain tumours are an ever‐challenging issue in neurology and related medical disciplines. This applies in particular to brain tumours associated with childhood‐onset epilepsies, in which seizures are the presenting and only neurological symptom, as our current understanding of the biology and clinic...

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Bibliographic Details
Published in:Epileptic disorders 2016-09, Vol.18 (3), p.240-251
Main Authors: Holthausen, Hans, Blümcke, Ingmar
Format: Article
Language:English
Subjects:
Brain Neoplasms - classification
Brain Neoplasms - complications
Brain Neoplasms - diagnosis
Brain Neoplasms - therapy
Child
classification
dysembryoplastic neuroepithelial tumour
Epilepsy - etiology
epileptology
ganglioglioma
glioma
Humans
long‐term epilepsy associated tumour (LEAT)
Male
Neuropathology
neurosurgery
neuro‐oncology
seizure
Tumors
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Summary:Brain tumours are an ever‐challenging issue in neurology and related medical disciplines. This applies in particular to brain tumours associated with childhood‐onset epilepsies, in which seizures are the presenting and only neurological symptom, as our current understanding of the biology and clinical behaviour of an individual tumour is far from being evidence‐based. Prospective and randomized clinical trials are lacking in the field of epilepsy‐associated tumours and a review of the current literature evokes more questions than provides answers. In this review, current areas of controversy in neuropathology, as well as terminology and classification, are discussed from an epileptologist's perspective. An illustrative case report exemplifies this controversy to further promote interdisciplinary discussion and novel research avenues towards comprehensive patient management in the near future.
ISSN:1294-9361
1950-6945
DOI:10.1684/epd.2016.0851