Haemoglobin and creatinine values as prognostic factors for outcome of concurrent radiochemotherapy in locally advanced head and neck cancers: Secondary results of two European randomized phase III trials (ARO 95-06, SAKK 10/94)

• Published in: Strahlentherapie und Onkologie 2016-08, Vol.192 (8), p.552-560
• Main Authors: Ghadjar, Pirus, Pöttgen, Christoph, Joos, Daniela, Hayoz, Stefanie, Baumann, Michael, Bodis, Stephan, Budach, Wilfried, Studer, Gabriela, Stromberger, Carmen, Zimmermann, Frank, Kaul, David, Plasswilm, Ludwig, Olze, Heidi, Bernier, Jacques, Wust, Peter, Aebersold, Daniel M., Budach, Volker
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers, Tumor - blood; Chemoradiotherapy - mortality; Chemoradiotherapy - utilization; Creatinine - blood; Disease-Free Survival; Europe - epidemiology; Female; Head and Neck Neoplasms - blood; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - therapy; Hemoglobins - analysis; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Prevalence; Prognosis; Radiotherapy; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Survival Rate; Treatment Outcome
• ISSN: 0179-7158; 1439-099X
• DOI: 10.1007/s00066-016-0999-3

Background To determine the influence of baseline laboratory values on treatment outcome in patients with locally advanced head and neck cancer (HNSCC). Methods Data of the randomized trials ARO 95 -06 ( n = 384) and SAKK 10 /94 ( n = 224) were pooled for a total sample size of 608 patients. Haemoglobin (Hb) and creatinine (Cr) were available at baseline and their association with locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), cancer-specific survival (CSS), and overall survival (OS) was analyzed using univariable and multivariable Cox regression models. Results A total of 580 and 564 patients were available with baseline Hb and Cr values in the pooled analysis. Univariable analyses revealed that lower baseline Hb values were significantly associated with decreased LRRFS, DMFS, CSS and OS. This effect remained significant for OS when the treatment arms (radiotherapy [RT] alone vs. chemoradiation [CRT]) were analyzed separately. Higher baseline Cr was associated with improved OS in the pooled analysis. Interestingly, the prognostic value of baseline Cr appeared to be limited to the subgroup of 284 patients who were treated with CRT. In the multivariable Cox regression model lower baseline Hb remained associated with decreased OS both in the patients who received CRT (HR 0.79, 95 % CI 0.66–0.94, p = 0.009) and in those patients who underwent RT alone (HR 0.67, 95 % CI 0.58–0.78, p < 0.001). Increased baseline Cr remained significantly associated with improved OS in patients who underwent CRT (HR 0.79, 95 % CI 0.69–0.92, p = 0.002) but not in those patients who underwent RT alone. Conclusions An association between lower baseline Hb and inferior treatment outcome was confirmed. Baseline Cr was introduced as a prognosticator of outcome after CRT for locally advanced HNSCC.