Skeletal muscle metabolic and ionic adaptations during intense exercise following sprint training in humans

• Published in: Journal of applied physiology (1985) 2000-11, Vol.89 (5), p.1793-1803
• Main Authors: Harmer, Alison R, McKenna, Michael J, Sutton, John R, Snow, Rodney J, Ruell, Patricia A, Booth, John, Thompson, Martin W, Mackay, Nadine A, Stathis, Chris G, Crameri, Regina M, Carey, Michael F, Eager, Diane M
• Format: Article
• Language: English
• Subjects: Acid-Base Equilibrium - physiology; Adaptation, Physiological - physiology; Adenosine Triphosphate - biosynthesis; Adult; Anaerobic Threshold - physiology; Biological and medical sciences; Carbon Dioxide - blood; Effects; Epinephrine - blood; Exercise; Exercise - physiology; Fundamental and applied biological sciences. Psychology; Glycogen - metabolism; Glycolysis - physiology; Heart Rate - physiology; Humans; Hydrogen-Ion Concentration; Ions; Lactic Acid - metabolism; Male; Metabolism; Muscle, Skeletal - metabolism; Muscular system; Norepinephrine - blood; Oxygen - blood; Oxygen Consumption - physiology; Physical Endurance - physiology; Potassium; Potassium - blood; Protons; Pulmonary Gas Exchange - physiology; Running - physiology; Striated muscle. Tendons; Vertebrates: osteoarticular system, musculoskeletal system
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.2000.89.5.1793

1  School of Exercise and Sport Science, The University of Sydney, Lidcombe, 1825; 2  School of Human Movement, Recreation and Performance, and 3  Exercise Metabolism Unit, School of Life Science and Technology, Centre for Rehabilitation, Exercise, and Sport Science, Victoria University of Technology, Footscray, 8011; and 4  School of Health Sciences, Deakin University, Burwood, 3125, Australia The effects of sprint training on muscle metabolism and ion regulation during intense exercise remain controversial. We employed a rigorous methodological approach, contrasting these responses during exercise to exhaustion and during identical work before and after training. Seven untrained men undertook 7 wk of sprint training. Subjects cycled to exhaustion at 130% pretraining peak oxygen uptake before (PreExh) and after training (PostExh), as well as performing another posttraining test identical to PreExh (PostMatch). Biopsies were taken at rest and immediately postexercise. After training in PostMatch, muscle and plasma lactate (Lac ) and H + concentrations, anaerobic ATP production rate, glycogen and ATP degradation, IMP accumulation, and peak plasma K + and norepinephrine concentrations were reduced ( P