Increased Bone Resorption: A Possible Pathophysiological Link Between Hypovitaminosis D and Peripheral Arterial Disease

• Published in: European journal of vascular and endovascular surgery 2016-09, Vol.52 (3), p.352-359
• Main Authors: Pasqualini, L, Ministrini, S, Macura, A, Marini, E, Leli, C, Siepi, D, Lombardini, R, Kararoudi, M.N, Scarponi, A.M, Schillaci, G, Pirro, M, Mannarino, E
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alkaline Phosphatase - blood; Ankle Brachial Index; Biomarkers - blood; Bone resorption; Bone Resorption - diagnosis; Bone Resorption - etiology; Bone Resorption - physiopathology; C-terminal telopeptide of type I collagen; Chi-Square Distribution; Collagen Type I - blood; Cross-Sectional Studies; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Odds Ratio; Peptides - blood; Peripheral arterial disease; Peripheral Arterial Disease - diagnostic imaging; Peripheral Arterial Disease - etiology; Peripheral Arterial Disease - physiopathology; Risk Factors; Severity of Illness Index; Surgery; Ultrasonography, Doppler; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D deficiency; Vitamin D Deficiency - complications; Vitamin D Deficiency - diagnosis; Vitamin D Deficiency - physiopathology
• ISSN: 1078-5884; 1532-2165
• DOI: 10.1016/j.ejvs.2016.04.022

Objective/Background Vitamin D deficiency has been associated with the prevalence and severity of peripheral arterial disease (PAD); nevertheless, data on bone turnover in patients with PAD is lacking. The present study investigates a possible relationship between the markers of bone turnover and the presence and severity of PAD. Methods The study examined 143 patients, with a mean ± SD age of 75.3 ± 8.5 years (range 50.0–93.0 years), of both sexes, admitted to a department of internal medicine. All patients underwent ankle brachial index (ABI) assessment by Doppler velocimetry. Serum levels of 25(OH) vitamin D and two markers of bone turnover, C-terminal telopeptide of type I collagen (sCTX) and bone isoenzyme of alkaline phosphatase, were measured. The differences between patients with normal ABI and patients with PAD were analyzed. Pearson and Spearman correlation coefficients were calculated and independent predictors were identified through a stepwise linear regression analysis. Odds ratios were calculated with a logistic regression model. Results Compared with patients with a normal ABI (≥0.90), patients with PAD (ABI