Lymphocyte populations in Parkinson’s disease and in rat models of parkinsonism

To assess the involvement of the immune system in Parkinson’s disease we studied the phenotype of circulating lymphocytes in 30 untreated and 34 treated patients. We found a numeric decrease in helper T cells (higher in CD4 +CD45RA + than in CD4 +CD29 +) and B cells, and a rise in activated, CD4 +CD...

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Bibliographic Details
Published in:Journal of neuroimmunology 2001-02, Vol.113 (1), p.146-152
Main Authors: Bas, Jordi, Calopa, Màtil, Mestre, Mariona, Mollevı́, David G., Cutillas, Blanca, Ambrosio, Santiago, Buendia, Enric
Format: Article
Language:English
Subjects:
Activation
Aged
Animals
CD4-Positive T-Lymphocytes - chemistry
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - immunology
Disease Models, Animal
Dopamine
Human
Humans
Leukocyte Common Antigens - analysis
Leukocyte Common Antigens - immunology
Lymphocyte Activation - immunology
Lymphocytes
Male
Middle Aged
MPTP Poisoning - immunology
Oxidopamine
Parkinson Disease - immunology
Parkinson’s disease
Rat
Rats
Rats, Sprague-Dawley
Receptors, Interleukin-2 - blood
Receptors, Interleukin-2 - immunology
Solubility
Sympatholytics
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Summary:To assess the involvement of the immune system in Parkinson’s disease we studied the phenotype of circulating lymphocytes in 30 untreated and 34 treated patients. We found a numeric decrease in helper T cells (higher in CD4 +CD45RA + than in CD4 +CD29 +) and B cells, and a rise in activated, CD4 +CD25 + lymphocytes that was correlated with lymphocyte depletion. All these alterations were independent of levodopa treatment. In addition, we performed striatal dopamine depletion in rats with either MPP + or 6-OHDA, showing that MPP + but not 6-OHDA can increase CD4 +CD25 + lymphocytes. Thus, mechanisms other than dopamine deficit may explain the immune activation in Parkinson’s disease.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(00)00422-7