26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans

Endogenous small interfering RNAs (endo-siRNAs) regulate diverse gene expression programs in eukaryotes by either binding and cleaving mRNA targets or mediating heterochromatin formation; however, the mechanisms of endo-siRNA biogenesis, sorting, and target regulation remain poorly understood. Here...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS 2009-11, Vol.106 (44), p.18674-18679
Main Authors:	Han, Ting, Manoharan, Arun Prasad, Harkins, Tim T, Bouffard, Pascal, Fitzpatrick, Colin, Chu, Diana S, Thierry-Mieg, Danielle, Thierry-Mieg, Jean, Kim, John K
Format:	Article
Language:	English
Subjects:	Animals biogenesis Biological Sciences Caenorhabditis elegans Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins - metabolism Embryos Eukaryotes eukaryotic cells Evolution & development Exoribonucleases - metabolism Fertility Gene expression Gene expression regulation Gene Expression Regulation, Developmental Gene Silencing Germ cells Germ Cells - metabolism guanine Guanine - metabolism heterochromatin Male Messenger RNA Nematodes Oocytes Ribonucleic acid RNA RNA polymerase RNA, Helminth - classification RNA, Helminth - metabolism RNA, Small Interfering - biosynthesis RNA, Small Interfering - classification RNA, Small Interfering - metabolism RNA-directed RNA polymerase Sequence Analysis, DNA Small interfering RNA Spermatogenesis Spermatogenesis - genetics Spermatozoa transcription (genetics) Zygote - metabolism
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