Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: a pilot study

Background and Aims A noninvasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for the diagnosis of EAC has not been previously studied. Methods Plasma samples...

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Bibliographic Details
Published in:Gastrointestinal endoscopy 2016-10, Vol.84 (4), p.597-603
Main Authors: Bhatt, Amit, MD, Parsi, Mansour A., MD, MPH, Stevens, Tyler, MD, Gabbard, Scott, MD, Kumaravel, Arthi, MD, Jang, Sunguk, MD, Grove, David, PhD, Lopez, Rocio, MS, Murthy, Sudish, MD, Vargo, John J., MD, MPH, Dweik, Raed, MD
Format: Article
Language:English
Subjects:
Acetonitriles - blood
Acrylonitrile - blood
Adenocarcinoma - blood
Adenocarcinoma - diagnosis
Adult
Aged
Area Under Curve
Butadienes - blood
Carbon Disulfide - blood
Case-Control Studies
Cross-Sectional Studies
Endoscopy, Digestive System
Esophageal Neoplasms - blood
Esophageal Neoplasms - diagnosis
Ethylamines - blood
Female
Gastroenterology and Hepatology
Gastroesophageal Reflux - blood
Gastroesophageal Reflux - diagnosis
Hemiterpenes - blood
Hexanes - blood
Humans
Hydrogen Sulfide - blood
Logistic Models
Male
Middle Aged
Multivariate Analysis
Pentanes - blood
Pilot Projects
Volatile Organic Compounds - blood
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Summary:Background and Aims A noninvasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for the diagnosis of EAC has not been previously studied. Methods Plasma samples were collected from subjects with EAC and GERD before endoscopy. Twenty-two preselected VOCs were analyzed with selected ion flow tube mass spectrometry. Results The headspaces from 39 plasma samples (20 EAC, 19 GERD) were analyzed. The levels of 9 VOCs (acetonitrile, acrylonitrile, carbon disulfide, isoprene, 1-heptene, 3-methylhexane, [E]-2-nonene, hydrogen sulfide, and triethylamine) were significantly altered in EAC patients compared with GERD patients. A multivariable logistic regression analysis was performed to build a model for the prediction of EAC. The model identified patients with EAC with an area under the curve of 0.83 (95% confidence interval, 0.67-0.98). Conclusions Plasma VOCs may be useful in diagnosing EAC. Larger studies are needed to confirm our pilot study observations.
ISSN:0016-5107
1097-6779
DOI:10.1016/j.gie.2015.11.031