Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age

• Published in: Gynecologic oncology 2016-10, Vol.143 (1), p.73-76
• Main Authors: Melamed, Alexander, MD MPH, Gockley, Allison A., MD, Joseph, Naima T., MD, Sun, Sue Yazaki, MD, Clapp, Mark A., MD MPH, Goldstein, Donald P., MD, Berkowitz, Ross S., MD, Horowitz, Neil S., MD
• Format: Article
• Language: English
• Subjects: Adult; African Continental Ancestry Group; Asian Continental Ancestry Group; Cross-Sectional Studies; Epidemiology; European Continental Ancestry Group; Female; Hematology, Oncology and Palliative Medicine; Hispanic Americans; Humans; Hydatidiform Mole - ethnology; Hydatidiform Mole - etiology; Maternal Age; Molar pregancy; Obstetrics and Gynecology; Pregnancy; Race-ethnicity; Risk Factors
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/j.ygyno.2016.07.117

Abstract Objective To quantify the effect of race/ethnicity on risk of complete and partial molar pregnancy. Methods We conducted a cross-sectional study including women who were followed for complete or partial mole and those who had a live singleton birth in a teaching hospital in the northeastern United States between 2000 and 2013. We calculated race/ethnicity-specific risk of complete and partial mole per 10,000 live births, and used logistic regression to estimate crude and age-adjusted relative risks (RR) of complete and partial mole. Results We identified 140 cases of complete mole, 115 cases of partial mole, and 105,942 live births. The risk of complete mole was 13 cases per 10,000 live births (95% confidence interval [CI] 11–16) and that of partial mole was 11 cases per 10,000 live births (95% CI 9–13). After age-adjustment, Asians were more likely to develop complete mole (RR 2.3 95% CI 1.4–3.8, p < 0.001) but less likely to develop partial mole (RR 0.2; 95% CI 0.04–0.7, p = 0.02) than whites. Blacks were significantly less likely than whites to develop partial mole (RR 0.4; 95% CI 0.2–0.8, p = 0.01) but only marginally less likely to develop complete mole (RR 0.6; 95% CI 0.3–1.0, p = 0.07). Hispanics were less likely than whites to develop complete mole (RR 0.4; 95% CI 0.2–0.7, p = 0.002) and partial mole (RR 0.4; 95% CI 0.2–0.9, p = 0.02). Conclusion Race/ethnicity is a significant risk factor for both complete and partial molar pregnancy in the northeastern United States.