Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Objective To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to that in patients with multiple sclerosis (MS) and healthy control subjects. Materials and methods Sixteen patients with NMOSD, 16 patients with MS and 16 healthy control subject...

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Bibliographic Details
Published in:Magma (New York, N.Y.) N.Y.), 2016-06, Vol.29 (3), p.535-541
Main Authors: Schumacher, Sophie, Pache, Florence, Bellmann-Strobl, Judith, Behrens, Janina, Dusek, Petr, Harms, Lutz, Ruprecht, Klemens, Nytrova, Petra, Chawla, Sanjeev, Niendorf, Thoralf, Kister, Ilya, Paul, Friedemann, Ge, Yulin, Wuerfel, Jens, Sinnecker, Tim
Format: Article
Language:English
Subjects:
Adult
Aged
Biology
Biomedical Engineering and Bioengineering
Brain - diagnostic imaging
Brain - pathology
Case-Control Studies
Central nervous system
Cohort Studies
Computer Appl. in Life Sciences
Density
Disease control
Estimates
Female
Health Informatics
Humans
Imaging
Inversions
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Neuromyelitis Optica - diagnostic imaging
Neuromyelitis Optica - pathology
Patients
Radiology
Research Article
Solid State Physics
Veins - diagnostic imaging
Veins - pathology
Young Adult
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Summary:Objective To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to that in patients with multiple sclerosis (MS) and healthy control subjects. Materials and methods Sixteen patients with NMOSD, 16 patients with MS and 16 healthy control subjects underwent 7.0-Tesla (7T) MRI. The imaging protocol included T 2 *-weighted (T 2 *w) fast low angle-shot (FLASH) and fluid-attenuated inversion recovery (FLAIR) sequences. The periventricular venous area (PVA) was manually determined by a blinded investigator in order to estimate the periventricular venous density in a region of interest-based approach. Results No significant differences in periventricular venous density indicated by PVA were detectable in NMOSD versus healthy controls ( p  = 0.226). In contrast, PVA was significantly reduced in MS patients compared to healthy controls ( p  = 0.013). Conclusion Unlike patients with MS, those suffering from NMOSD did not show reduced venous visibility. This finding may underscore primary and secondary pathophysiological differences between these two distinct diseases of the central nervous system.
ISSN:0968-5243
1352-8661
DOI:10.1007/s10334-016-0554-3