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Application of a NMR-based untargeted quantitative metabonomic approach to screen for illicit salbutamol administration in cattle
The use of metabonomic methodologies to identify illicit salbutamol administration in cattle has not been previously investigated. In this study, a nuclear magnetic resonance (NMR)-based untargeted quantitative metabonomic approach was applied to discriminate biofluid samples (plasma and urine) obta...
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| Published in: | Analytical and bioanalytical chemistry 2016-07, Vol.408 (17), p.4777-4783 |
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| creator | Tang, Chaohua Zhang, Kai Liang, Xiaowei Zhao, Qingyu Zhang, Junmin |
| description | The use of metabonomic methodologies to identify illicit salbutamol administration in cattle has not been previously investigated. In this study, a nuclear magnetic resonance (NMR)-based untargeted quantitative metabonomic approach was applied to discriminate biofluid samples (plasma and urine) obtained from cattle before and after salbutamol treatment. Six male cattle (265.7 ± 3.9 kg) were fed salbutamol (0.15 mg/kg body weight) for 21 consecutive days. Plasma and urine samples were collected before and after treatment. By the use of targeted profiling, 46 and 43 metabolites in plasma and urine, respectively, were quantified, of which 9 and 11 metabolites were significantly affected (
P
1.0, which implies that these metabolites may serve as potential biomarkers for salbutamol treatment. These findings suggest the potential value of NMR-based untargeted quantitative metabonomic methodologies for plasma and urine analyses as a screening technique for detection of illicit salbutamol usage in cattle. |
| doi_str_mv | 10.1007/s00216-016-9571-3 |
| format | article |
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P
< 0.05) by salbutamol treatment. Partial least squares discriminant analysis showed that both plasma and urine samples collected after treatment were well separated from those before treatment, with
Q
2
values of 0.56 and 0.573 for plasma and urine samples, respectively. The variable importance plot (VIP) scores of glucose and lactate in plasma, and urine, hippurate, acetate, glycine, formate,
n
-phenylacetyl, benzoate, and phenylacetate in urine were >1.0, which implies that these metabolites may serve as potential biomarkers for salbutamol treatment. These findings suggest the potential value of NMR-based untargeted quantitative metabonomic methodologies for plasma and urine analyses as a screening technique for detection of illicit salbutamol usage in cattle.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-016-9571-3</identifier><identifier>PMID: 27116419</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetates ; Albuterol ; Albuterol - administration & dosage ; Analytical Chemistry ; Animal sciences ; Animals ; Biochemistry ; Biomarkers ; Biosensors ; Body Fluids - chemistry ; Body weight ; Cattle ; Characterization and Evaluation of Materials ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Discriminant analysis ; Drugs ; Food Science ; Formates ; Health aspects ; Identification and classification ; Illicit ; Laboratory Medicine ; Magnetic Resonance Spectroscopy - methods ; Male ; Mass spectrometry ; Metabolism ; Metabolites ; Metabolomics - methods ; Methods ; Monitoring/Environmental Analysis ; NMR ; Nuclear magnetic resonance ; Nuclear magnetic resonance spectroscopy ; Physiology ; Plasma ; Research Paper ; Scientific imaging ; Urine ; Zoology</subject><ispartof>Analytical and bioanalytical chemistry, 2016-07, Vol.408 (17), p.4777-4783</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-ae0f73972f164676cf7ba6484e604a3590e8cd5772ec621d3a8e7e3960b3acb73</citedby><cites>FETCH-LOGICAL-c542t-ae0f73972f164676cf7ba6484e604a3590e8cd5772ec621d3a8e7e3960b3acb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27116419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Chaohua</creatorcontrib><creatorcontrib>Zhang, Kai</creatorcontrib><creatorcontrib>Liang, Xiaowei</creatorcontrib><creatorcontrib>Zhao, Qingyu</creatorcontrib><creatorcontrib>Zhang, Junmin</creatorcontrib><title>Application of a NMR-based untargeted quantitative metabonomic approach to screen for illicit salbutamol administration in cattle</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>The use of metabonomic methodologies to identify illicit salbutamol administration in cattle has not been previously investigated. In this study, a nuclear magnetic resonance (NMR)-based untargeted quantitative metabonomic approach was applied to discriminate biofluid samples (plasma and urine) obtained from cattle before and after salbutamol treatment. Six male cattle (265.7 ± 3.9 kg) were fed salbutamol (0.15 mg/kg body weight) for 21 consecutive days. Plasma and urine samples were collected before and after treatment. By the use of targeted profiling, 46 and 43 metabolites in plasma and urine, respectively, were quantified, of which 9 and 11 metabolites were significantly affected (
P
< 0.05) by salbutamol treatment. Partial least squares discriminant analysis showed that both plasma and urine samples collected after treatment were well separated from those before treatment, with
Q
2
values of 0.56 and 0.573 for plasma and urine samples, respectively. The variable importance plot (VIP) scores of glucose and lactate in plasma, and urine, hippurate, acetate, glycine, formate,
n
-phenylacetyl, benzoate, and phenylacetate in urine were >1.0, which implies that these metabolites may serve as potential biomarkers for salbutamol treatment. These findings suggest the potential value of NMR-based untargeted quantitative metabonomic methodologies for plasma and urine analyses as a screening technique for detection of illicit salbutamol usage in cattle.</description><subject>Acetates</subject><subject>Albuterol</subject><subject>Albuterol - administration & dosage</subject><subject>Analytical Chemistry</subject><subject>Animal sciences</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biosensors</subject><subject>Body Fluids - chemistry</subject><subject>Body weight</subject><subject>Cattle</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Discriminant analysis</subject><subject>Drugs</subject><subject>Food Science</subject><subject>Formates</subject><subject>Health aspects</subject><subject>Identification and classification</subject><subject>Illicit</subject><subject>Laboratory Medicine</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics - methods</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear magnetic resonance spectroscopy</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Research Paper</subject><subject>Scientific 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chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Chaohua</au><au>Zhang, Kai</au><au>Liang, Xiaowei</au><au>Zhao, Qingyu</au><au>Zhang, Junmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of a NMR-based untargeted quantitative metabonomic approach to screen for illicit salbutamol administration in cattle</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>408</volume><issue>17</issue><spage>4777</spage><epage>4783</epage><pages>4777-4783</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>The use of metabonomic methodologies to identify illicit salbutamol administration in cattle has not been previously investigated. In this study, a nuclear magnetic resonance (NMR)-based untargeted quantitative metabonomic approach was applied to discriminate biofluid samples (plasma and urine) obtained from cattle before and after salbutamol treatment. Six male cattle (265.7 ± 3.9 kg) were fed salbutamol (0.15 mg/kg body weight) for 21 consecutive days. Plasma and urine samples were collected before and after treatment. By the use of targeted profiling, 46 and 43 metabolites in plasma and urine, respectively, were quantified, of which 9 and 11 metabolites were significantly affected (
P
< 0.05) by salbutamol treatment. Partial least squares discriminant analysis showed that both plasma and urine samples collected after treatment were well separated from those before treatment, with
Q
2
values of 0.56 and 0.573 for plasma and urine samples, respectively. The variable importance plot (VIP) scores of glucose and lactate in plasma, and urine, hippurate, acetate, glycine, formate,
n
-phenylacetyl, benzoate, and phenylacetate in urine were >1.0, which implies that these metabolites may serve as potential biomarkers for salbutamol treatment. These findings suggest the potential value of NMR-based untargeted quantitative metabonomic methodologies for plasma and urine analyses as a screening technique for detection of illicit salbutamol usage in cattle.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27116419</pmid><doi>10.1007/s00216-016-9571-3</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetates Albuterol Albuterol - administration & dosage Analytical Chemistry Animal sciences Animals Biochemistry Biomarkers Biosensors Body Fluids - chemistry Body weight Cattle Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Discriminant analysis Drugs Food Science Formates Health aspects Identification and classification Illicit Laboratory Medicine Magnetic Resonance Spectroscopy - methods Male Mass spectrometry Metabolism Metabolites Metabolomics - methods Methods Monitoring/Environmental Analysis NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Physiology Plasma Research Paper Scientific imaging Urine Zoology |
| title | Application of a NMR-based untargeted quantitative metabonomic approach to screen for illicit salbutamol administration in cattle |
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