Composite aerogels based on dialdehyde nanocellulose and collagen for potential applications as wound dressing and tissue engineering scaffold

Nanocellulose and collagen are all natural polymer materials, and their combination could expand the mode and scope of applications. Employing a mild chemical purification together with the subsequent ultrasonic treatment, the nanocellulose fibers (NCFs) were isolated from wood powder, and were then...

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Bibliographic Details
Published in:Composites science and technology 2014-04, Vol.94, p.132-138
Main Authors: Lu, Tianhong, Li, Qing, Chen, Wenshuai, Yu, Haipeng
Format: Article
Language:English
Subjects:
A. Functional composites
A. Nano Composites
Aerogels
Applied sciences
Biological and medical sciences
Collagens
Composites
Crosslinking
Dressing
Exact sciences and technology
Fibers
Forms of application and semi-finished materials
Medical sciences
Nanostructure
Polymer industry, paints, wood
Scaffolds
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Tissue engineering
Tissue engineering scaffold
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Summary:Nanocellulose and collagen are all natural polymer materials, and their combination could expand the mode and scope of applications. Employing a mild chemical purification together with the subsequent ultrasonic treatment, the nanocellulose fibers (NCFs) were isolated from wood powder, and were then oxidized into dialdehyde NCFs by sodium periodate, which offers active sites for introducing collagen. The dialdehyde NCFs and collagen were crosslinked together through the bonds of Schiff base. The dialdehyde NCFs act as matrix to guide the growth of collagen, and through the chemical crosslinkage, collagen grew along dialdehyde NCFs and formed the composite aerogels. The as-prepared NCF/collagen composite aerogels, consisting of the membranes interwoven by NCF/collagen composite fibers, exhibited low-densities between 0.02 and 0.03gcm−3, high-porosities ranged from 90% to 95%, and strong water absorption up to 4000%. The aerogels also exhibited good biocompatibility as well as high level of cell activity and proliferation, which may be suitable for biological wound dressings and tissue engineering scaffolds.
ISSN:0266-3538
1879-1050
DOI:10.1016/j.compscitech.2014.01.020