Prognostic factors affecting survival in non-small cell lung carcinoma patients with malignant pleural effusions

Background and Aims Lung cancer is the most common cause of malignant pleural effusions (MPEs). For patients with lung cancer and MPE, median survival is only 3–4 months. The aim of this study was to evaluate lung cancer patients with MPE by clinical and laboratory findings on admission, and determi...

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Published in:The clinical respiratory journal 2016-11, Vol.10 (6), p.791-799
Main Authors: Kasapoglu, Umut Sabri, Arınç, Sibel, Gungor, Sinem, Irmak, Ilim, Guney, Pinar, Aksoy, Ferda, Bandak, Dilek, Hazar, Armagan
Format: Article
Language:English
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Summary:Background and Aims Lung cancer is the most common cause of malignant pleural effusions (MPEs). For patients with lung cancer and MPE, median survival is only 3–4 months. The aim of this study was to evaluate lung cancer patients with MPE by clinical and laboratory findings on admission, and determine 2‐year survival rate and prognostic factors. Methods Between 2008 and 2011, we examined 199 cases of non‐small cell lung carcinoma with MPE. Demographic factors of patients, tumor characteristics, treatment delivered and laboratory parameters affecting prognosis were evaluated. Survival rates were estimated by Kaplan–Meier method. Significance of each prognostic factors selected by univariate analysis were confirmed using Cox regression model. Results The study included 139 (69.8%) male and 60 (30.2%) female patients with a median age of 64 (30–85) years. Median overall survival was 4.4 months. Adenocarcinoma was the leading cause of MPE with 80.4%. A univariate analysis showed that factors affecting mortality included gender (P 
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12292