Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

• Published in: Epilepsy & behavior 2017-06, Vol.71 (Pt B), p.243-249
• Main Authors: Castro, Gabriel Perfeito, Medeiros, Daniel de Castro, Guarnieri, Leonardo de Oliveira, Mourão, Flávio Afonso Gonçalves, Pinto, Hyorrana Priscila Pereira, Pereira, Grace Schenatto, Moraes, Márcio Flávio Dutra
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation - adverse effects; Animals; Avoidance Learning - physiology; Behavior, Animal - physiology; Comorbidities; Disease Models, Animal; Disease Susceptibility - psychology; Epilepsy; Epilepsy, Reflex - genetics; Epilepsy, Reflex - physiopathology; Epilepsy, Reflex - psychology; Genetic Predisposition to Disease - genetics; Genetic Predisposition to Disease - psychology; Male; Maze Learning - physiology; Neurology; Psychiatric disorder; Rats; Rats, Wistar; Seizure predisposition; Seizures - genetics; Seizures - physiopathology; Seizures - psychology; Wistar audiogenic rat
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2015.08.039

Abstract Accumulating evidence from different animal models has contributed to the understanding of the bidirectional comorbidity associations between the epileptic condition and behavioral abnormalities. A strain of animals inbred to enhance seizure predisposition to high-intensity sound stimulation, the Wistar audiogenic rat (WAR), underwent several behavioral tests: forced swim test (FST), open-field test (OFT), sucrose preference test (SPT), elevated plus maze (EPM), social preference (SP), marble burying test (MBT), inhibitory avoidance (IAT), and two-way active avoidance (TWAA). The choice of tests aimed to investigate the correlation between underlying circuits believed to be participating in both WAR's innate susceptibility to sound-triggered seizures and the neurobiological substrates associated with test performance. Comparing WAR with its Wistar counterpart (i.e., resistant to audiogenic seizures) showed that WARs present behavioral despair traits (e.g., increased FST immobility) but no evidence of anhedonic behavior (e.g., increased sucrose consumption in SPT) or social impairment (e.g., no difference regarding juvenile exploration in SP). In addition, tests suggested that WARs are unable to properly evaluate degrees of aversiveness (e.g., performance on OFT, EPM, MBT, IAT, and TWAA). The particularities of the WAR model opens new venues to further untangle the neurobiology underlying the co-morbidity of behavioral disorders and epilepsy. This article is part of a Special Issue entitled “Genetic Models—Epilepsy”.