α‐Defensins and bacterial/permeability‐increasing protein as new markers of childhood obesity

Summary Objectives The aim of this paper is to test whether α‐defensins and bacterial/permeability‐increasing protein were related to obesity and cardiovascular risk factors in prepubertal children. Methods Plasma α‐defensins and bacterial/permeability‐increasing protein, body mass index (BMI), wais...

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Published in:Pediatric obesity 2017-04, Vol.12 (2), p.e10-e13
Main Authors: Prats‐Puig, A., Gispert‐Saüch, M., Carreras‐Badosa, G., Osiniri, I., Soriano‐Rodríguez, P., Planella‐Colomer, M., Zegher, F., Ibánez, L., Bassols, J., López‐Bermejo, A.
Format: Article
Language:English
Subjects:
alpha-Defensins - blood
Anthropometry
Antimicrobial Cationic Peptides - blood
bacterial/permeability‐increasing protein
Biomarkers - blood
Blood Pressure
Blood Proteins
Cardiovascular Diseases - blood
Carotid Intima-Media Thickness
Child
children
Cross-Sectional Studies
Female
Humans
insulin resistance
Longitudinal Studies
Male
obesity
Pediatric Obesity - blood
Risk Factors
α‐Defensins
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Summary:Summary Objectives The aim of this paper is to test whether α‐defensins and bacterial/permeability‐increasing protein were related to obesity and cardiovascular risk factors in prepubertal children. Methods Plasma α‐defensins and bacterial/permeability‐increasing protein, body mass index (BMI), waist circumference, systolic blood pressure (SBP), carotid intima media thickness (cIMT), HOMA‐IR and HMW‐adiponectin were assessed. Results In a cross‐sectional study (N = 250), higher α‐defensins concentrations were positively associated with BMI, waist, SBP, cIMT, HOMA‐IR and negative correlated with HMW‐adiponectin (all between r = 0.191 and r = 0.377, p ≤ 0.01 and p ≤ 0.0001). Conversely, plasma bacterial/permeability‐increasing protein concentrations presented inversed associated with the same parameters (all between r = −0.124 and r = −0.329; p ≤ 0.05 and p ≤ 0.0001). In a longitudinal study (N = 91), α‐defensins at age 7 were associated with BMI (β = 0.189, p = 0.002; model R2 = 0.847) and waist (β = 0.241, pthinsp;= 0.001; model R2 = 0.754) at age 10. Conclusions α‐Defensins and bacterial/permeability‐increasing protein may be the markers of childhood obesity. Increased concentrations of α‐defensins may predict BMI and abdominal fat deposition in children.
ISSN:2047-6302
2047-6310
DOI:10.1111/ijpo.12118