Maternal high-fat feeding in pregnancy programs atherosclerotic lesion size in the ApoE3 Leiden mouse

Periods of rapid growth seen during the early stages of fetal development, including cell proliferation and differentiation, are greatly influenced by the maternal environment. We demonstrate here that over-nutrition, specifically exposure to a high-fat diet in utero, programed the extent of atheros...

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Bibliographic Details
Published in:Journal of developmental origins of health and disease 2016-06, Vol.7 (3), p.290-297
Main Authors: Tarling, E. J., Ryan, K. J. P., Austin, R., Kugler, S. J., Salter, A. M., Langley-Evans, S. C.
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Cholesterol
Deoxyribonucleic acid
Diet
DNA
DNA methylation
Fatty acids
Females
Gene expression
Industrialized nations
Males
Nutrition research
Original Article
Pregnancy
Rodents
Weaning
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Summary:Periods of rapid growth seen during the early stages of fetal development, including cell proliferation and differentiation, are greatly influenced by the maternal environment. We demonstrate here that over-nutrition, specifically exposure to a high-fat diet in utero, programed the extent of atherosclerosis in the offspring of ApoE*3 Leiden transgenic mice. Pregnant ApoE*3 Leiden mice were fed either a control chow diet (2.8% fat, n=12) or a high-fat, moderate-cholesterol diet (MHF, 19.4% fat, n=12). Dams were fed the chow diet during the suckling period. At 28 days postnatal age wild type and ApoE*3 Leiden offspring from chow or MHF-fed mothers were fed either a control chow diet (n=37) or a diet rich in cocoa butter (15%) and cholesterol (0.25%), for 14 weeks to induce atherosclerosis (n=36). Offspring from MHF-fed mothers had 1.9-fold larger atherosclerotic lesions (P
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174416000027