Fetal brain imaging following laser surgery in twin‐to‐twin surgery

• Published in: BJOG : an international journal of obstetrics and gynaecology 2018-08, Vol.125 (9), p.1186-1191
• Main Authors: Stirnemann, J, Chalouhi, G, Essaoui, M, Bahi‐Buisson, N, Sonigo, P, Millischer, A‐E, Lapillonne, A, Guigue, V, Salomon, LJ, Ville, Y
• Format: Article
• Language: English
• Subjects: Brain; Brain - diagnostic imaging; Brain - embryology; Brain damage; Brain injury; Female; Fetofetal Transfusion - surgery; Fetoscopy - adverse effects; Fetoscopy - methods; Fetus - diagnostic imaging; Fetus - embryology; Fetuses; Gestation; Humans; Hypoxia, Brain - diagnostic imaging; Hypoxia, Brain - embryology; Hypoxia, Brain - etiology; laser; Laser Coagulation - adverse effects; Laser Coagulation - methods; Magnetic resonance imaging; MRI; Neuroimaging; Neuroimaging - methods; NMR; Nuclear magnetic resonance; Placenta; Postoperative Complications - diagnostic imaging; Postoperative Complications - etiology; Pregnancy; Prenatal Injuries - diagnostic imaging; Prenatal Injuries - etiology; Retrospective Studies; Surgery; TAPS; twin–twin transfusion syndrome; Ultrasonic imaging; Ultrasound
• ISSN: 1470-0328; 1471-0528
• DOI: 10.1111/1471-0528.14162

Objective To describe the incidence and nature of prenatal brain damage following fetoscopic laser selective coagulation (FLSC) of placental vessels for twin‐to‐twin transfusion syndrome (TTTS). Design Retrospective observational study. Setting Single center cohort. Population All consecutive cases referred for TTTS treated by FLSC between 2003 and 2015. Methods After the FLSC, patients were followed weekly by ultrasound. Fetal magnetic resonance imaging (MRI) scans were systematically planned at 30–32 weeks of gestation. Main outcome measures Brain damage diagnosed prenatally by ultrasound or MRI. Results In total, 1023 cases were reviewed. Brain damage was diagnosed prenatally in 22/1023 (2.1%) cases. Diagnosis was performed by ultrasound prior to MRI in 18 (82%) cases. All lesions were within the spectrum of ischaemic haemorrhagic lesions. Postoperative twin anaemia polycythaemia sequence and recurrence of TTTS were significantly associated with brain damage. Conclusion The incidence of prenatal brain damage is low following FSLC, and is strongly associated with incomplete surgery. Tweetable Following FSLC for TTTS, prenatal brain damage occurs in 2% of cases and is associated with incomplete surgery. Tweetable Following FSLC for TTTS, prenatal brain damage occurs in 2% of cases and is associated with incomplete surgery.