Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers

• Published in: Clinical and experimental nephrology 2017-06, Vol.21 (3), p.457-464
• Main Authors: Imaizumi, Takahiro, Ando, Masahiko, Nakatochi, Masahiro, Maruyama, Shoichi, Yasuda, Yoshinari, Honda, Hiroyuki, Kuwatsuka, Yachiyo, Kato, Sawako, Kondo, Takaaki, Iwata, Masamitsu, Nakashima, Toru, Yasui, Hiroshi, Takamatsu, Hideki, Okajima, Hiroshi, Yoshida, Yasuko, Matsuo, Seiichi
• Format: Article
• Language: English
• Subjects: Adult; Asian Continental Ancestry Group - genetics; Atrial Natriuretic Factor - genetics; Blood pressure; Blood Pressure - genetics; Chi-Square Distribution; Cross-Sectional Studies; Employment; Feeding Behavior; Gene-Environment Interaction; Genetic diversity; Genetic Predisposition to Disease; Humans; Hypertension; Hypertension - diagnosis; Hypertension - ethnology; Hypertension - genetics; Hypertension - physiopathology; Japan - epidemiology; Linear Models; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; Nephrology; Occupational Health; Original Article; Phenotype; Polymorphism; Polymorphism, Single Nucleotide; Risk Factors; Sex Factors; Single-nucleotide polymorphism; Sodium, Dietary - adverse effects; Urology; Workers
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-016-1315-3

Background Blood pressure is influenced by hereditary factors and dietary habits. The objective of this study was to examine the effect of dietary salt consumption and single-nucleotide polymorphisms (SNPs) on blood pressure (BP). Methods This was a cross-sectional analysis of 2728 male participants who participated in a health examination in 2009. Average dietary salt consumption was estimated using electronically collected meal purchase data from cafeteria. A multivariate analysis, adjusting for clinically relevant factors, was conducted to examine whether the effect on BP of salt consumption, SNPs, and interaction between salt consumption and each SNP. This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity. Results BP was not significantly associated with SNPs or salt consumption. The interaction between salt consumption and SNPs with systolic BP showed a significant association in NPPA rs5063 (Val32Met) ( P  = 0.023) and a marginal trend toward significance in rs4961 and rs1050450 ( P  = 0.060 and 0.067, respectively). Conclusion The effect of salt consumption on BP differed by genotype. Dietary salt consumption and genetic variation can predict a high risk of hypertension.