Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis

Objective The disease process in rheumatoid arthritis (RA) starts years before the clinical diagnosis is made, and elevated levels of disease‐specific autoantibodies can be detected during this period. Early responses to known or novel autoantigens likely drive the eventual production of pathogenic...

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Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2016-10, Vol.68 (10), p.2372-2383
Main Authors: Kinslow, Jennifer D., Blum, Lisa K., Deane, Kevin D., Demoruelle, M. Kristen, Okamoto, Yuko, Parish, Mark C., Kongpachith, Sarah, Lahey, Lauren J., Norris, Jill M., Robinson, William H., Holers, V. Michael
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - immunology
Autoantibodies - genetics
Autoantibodies - immunology
Female
Genes, Immunoglobulin Heavy Chain - genetics
Genes, Immunoglobulin Light Chain - genetics
High-Throughput Nucleotide Sequencing
Humans
Immunoglobulin A - genetics
Immunoglobulin A - immunology
Immunoglobulin G - genetics
Immunoglobulin G - immunology
Male
Middle Aged
Peptides, Cyclic - immunology
Plasma Cells - immunology
Rheumatoid arthritis
Rheumatoid Factor - immunology
Risk
Sequence Analysis, DNA
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Summary:Objective The disease process in rheumatoid arthritis (RA) starts years before the clinical diagnosis is made, and elevated levels of disease‐specific autoantibodies can be detected during this period. Early responses to known or novel autoantigens likely drive the eventual production of pathogenic autoimmunity. Importantly, the presence of disease‐specific autoantibodies can identify individuals who are at high risk of developing RA but who do not currently have arthritis. The goal of the current study was to characterize plasmablasts from individuals at risk of developing RA. Methods We investigated antibody‐secreting plasmablasts derived from a well‐characterized cohort of individuals who were at risk of developing RA, based on RA‐related serum autoantibody positivity, as compared to patients with early (
ISSN:2326-5191
2326-5205
DOI:10.1002/art.39771