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Low serum biotin in Japanese children fed with hydrolysate formula
Background Given that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin‐binding a...
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| Published in: | Pediatrics international 2016-09, Vol.58 (9), p.867-871 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4767-3992143c85def8458b3c70c73a9cbd5764b4a61c2bf7457182b463bb6d18248f3 |
| container_end_page | 871 |
| container_issue | 9 |
| container_start_page | 867 |
| container_title | Pediatrics international |
| container_volume | 58 |
| creator | Sato, Yasuhiro Wakabayashi, Kenji Ogawa, Eishin Kodama, Hiroko Mimaki, Masakazu |
| description | Background
Given that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin‐binding assay.
Methods
A commercially available ELISA kit was used for the measurement of biotin in 54 types of formula, including hydrolysate formulas for milk allergy, as well as in breast milk and in the sera of 27 infants fed with these formulas.
Results
The biotin content reached the recommended value in only five formulas. All of the hydrolysate formulas and more than half of the special formulas contained biotin |
| doi_str_mv | 10.1111/ped.12937 |
| format | article |
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Given that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin‐binding assay.
Methods
A commercially available ELISA kit was used for the measurement of biotin in 54 types of formula, including hydrolysate formulas for milk allergy, as well as in breast milk and in the sera of 27 infants fed with these formulas.
Results
The biotin content reached the recommended value in only five formulas. All of the hydrolysate formulas and more than half of the special formulas contained biotin <0.1 μg/dL. Serum biotin was low in infants fed only with the hydrolysate formulas, and one of them had alopecia related to biotin deficiency.
Conclusion
While many were asymptomatic, infants fed with formulas lacking biotin are at risk of developing symptomatic disease. The addition of biotin to breast milk substitutes was finally approved in the middle of 2014, however pediatricians in Japan should still be vigilant with regard to nutritional biotin deficiency in infants for the time being.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.12937</identifier><identifier>PMID: 26824516</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Allergies ; Alopecia ; Avidin ; Baby foods ; Biotin ; Biotin - blood ; Biotin - pharmacokinetics ; biotin deficiency ; Breast milk ; Breastfeeding & lactation ; Child, Preschool ; Children ; Enzyme-linked immunosorbent assay ; Female ; Food allergies ; Health risks ; Humans ; hydrolysate formula ; Infant ; Infant Formula - chemistry ; Infant Nutritional Physiological Phenomena - physiology ; Infant, Newborn ; Infants ; Japan ; Male ; Milk ; milk allergy ; Nutritional Status ; Pediatrics ; Protein Hydrolysates - administration & dosage ; Vitamin B</subject><ispartof>Pediatrics international, 2016-09, Vol.58 (9), p.867-871</ispartof><rights>2016 Japan Pediatric Society</rights><rights>2016 Japan Pediatric Society.</rights><rights>Copyright © 2016 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4767-3992143c85def8458b3c70c73a9cbd5764b4a61c2bf7457182b463bb6d18248f3</citedby><cites>FETCH-LOGICAL-c4767-3992143c85def8458b3c70c73a9cbd5764b4a61c2bf7457182b463bb6d18248f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26824516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Yasuhiro</creatorcontrib><creatorcontrib>Wakabayashi, Kenji</creatorcontrib><creatorcontrib>Ogawa, Eishin</creatorcontrib><creatorcontrib>Kodama, Hiroko</creatorcontrib><creatorcontrib>Mimaki, Masakazu</creatorcontrib><title>Low serum biotin in Japanese children fed with hydrolysate formula</title><title>Pediatrics international</title><addtitle>Pediatrics International</addtitle><description>Background
Given that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin‐binding assay.
Methods
A commercially available ELISA kit was used for the measurement of biotin in 54 types of formula, including hydrolysate formulas for milk allergy, as well as in breast milk and in the sera of 27 infants fed with these formulas.
Results
The biotin content reached the recommended value in only five formulas. All of the hydrolysate formulas and more than half of the special formulas contained biotin <0.1 μg/dL. Serum biotin was low in infants fed only with the hydrolysate formulas, and one of them had alopecia related to biotin deficiency.
Conclusion
While many were asymptomatic, infants fed with formulas lacking biotin are at risk of developing symptomatic disease. The addition of biotin to breast milk substitutes was finally approved in the middle of 2014, however pediatricians in Japan should still be vigilant with regard to nutritional biotin deficiency in infants for the time being.</description><subject>Adult</subject><subject>Allergies</subject><subject>Alopecia</subject><subject>Avidin</subject><subject>Baby foods</subject><subject>Biotin</subject><subject>Biotin - blood</subject><subject>Biotin - pharmacokinetics</subject><subject>biotin deficiency</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Food allergies</subject><subject>Health risks</subject><subject>Humans</subject><subject>hydrolysate formula</subject><subject>Infant</subject><subject>Infant Formula - chemistry</subject><subject>Infant Nutritional Physiological Phenomena - physiology</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Japan</subject><subject>Male</subject><subject>Milk</subject><subject>milk allergy</subject><subject>Nutritional Status</subject><subject>Pediatrics</subject><subject>Protein Hydrolysates - administration & dosage</subject><subject>Vitamin B</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkUtLxDAUhYMovhf-ASm40UXHvJMuHd_DoCK-diFJU6baTsekZZx_b3QcF4Li5cK9hO8cbjgA7CDYQ7EOJy7vIZwRsQTWEaU4xRA-LcedYJlKyMUa2AjhGUIohaSrYA1ziSlDfB30h800Cc53dWLKpi3HSeyBnuixCy6xo7LKvRsnhcuTadmOktEs9001C7p1SdH4uqv0FlgpdBXc9tfcBPdnp3fHF-nw-vzy-GiYWiq4SEmWYUSJlSx3haRMGmIFtILozJqcCU4N1RxZbApBmUASG8qJMTyPK5UF2QT7c9-Jb147F1pVl8G6qoq3Nl1QERNSsij-D8ow4lTiiO79QJ-bzo_jR1QkYlFKs7-oj-vQJxapgzllfROCd4Wa-LLWfqYQVB9JqZiU-kwqsrtfjp2p4-uCXEQTgcM5MC0rN_vdSd2cniws07miDK17-1Zo_6K4IIKpx6tzNRyIB9jnt4qRdz8mqHU</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Sato, Yasuhiro</creator><creator>Wakabayashi, Kenji</creator><creator>Ogawa, Eishin</creator><creator>Kodama, Hiroko</creator><creator>Mimaki, Masakazu</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Low serum biotin in Japanese children fed with hydrolysate formula</title><author>Sato, Yasuhiro ; Wakabayashi, Kenji ; Ogawa, Eishin ; Kodama, Hiroko ; Mimaki, Masakazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4767-3992143c85def8458b3c70c73a9cbd5764b4a61c2bf7457182b463bb6d18248f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Allergies</topic><topic>Alopecia</topic><topic>Avidin</topic><topic>Baby foods</topic><topic>Biotin</topic><topic>Biotin - blood</topic><topic>Biotin - pharmacokinetics</topic><topic>biotin deficiency</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Food allergies</topic><topic>Health risks</topic><topic>Humans</topic><topic>hydrolysate formula</topic><topic>Infant</topic><topic>Infant Formula - chemistry</topic><topic>Infant Nutritional Physiological Phenomena - physiology</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Japan</topic><topic>Male</topic><topic>Milk</topic><topic>milk allergy</topic><topic>Nutritional Status</topic><topic>Pediatrics</topic><topic>Protein Hydrolysates - administration & dosage</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Yasuhiro</creatorcontrib><creatorcontrib>Wakabayashi, Kenji</creatorcontrib><creatorcontrib>Ogawa, Eishin</creatorcontrib><creatorcontrib>Kodama, Hiroko</creatorcontrib><creatorcontrib>Mimaki, Masakazu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Yasuhiro</au><au>Wakabayashi, Kenji</au><au>Ogawa, Eishin</au><au>Kodama, Hiroko</au><au>Mimaki, Masakazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum biotin in Japanese children fed with hydrolysate formula</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatrics International</addtitle><date>2016-09</date><risdate>2016</risdate><volume>58</volume><issue>9</issue><spage>867</spage><epage>871</epage><pages>867-871</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
Given that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin‐binding assay.
Methods
A commercially available ELISA kit was used for the measurement of biotin in 54 types of formula, including hydrolysate formulas for milk allergy, as well as in breast milk and in the sera of 27 infants fed with these formulas.
Results
The biotin content reached the recommended value in only five formulas. All of the hydrolysate formulas and more than half of the special formulas contained biotin <0.1 μg/dL. Serum biotin was low in infants fed only with the hydrolysate formulas, and one of them had alopecia related to biotin deficiency.
Conclusion
While many were asymptomatic, infants fed with formulas lacking biotin are at risk of developing symptomatic disease. The addition of biotin to breast milk substitutes was finally approved in the middle of 2014, however pediatricians in Japan should still be vigilant with regard to nutritional biotin deficiency in infants for the time being.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>26824516</pmid><doi>10.1111/ped.12937</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1328-8067 |
| ispartof | Pediatrics international, 2016-09, Vol.58 (9), p.867-871 |
| issn | 1328-8067 1442-200X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1827885745 |
| source | Wiley |
| subjects | Adult Allergies Alopecia Avidin Baby foods Biotin Biotin - blood Biotin - pharmacokinetics biotin deficiency Breast milk Breastfeeding & lactation Child, Preschool Children Enzyme-linked immunosorbent assay Female Food allergies Health risks Humans hydrolysate formula Infant Infant Formula - chemistry Infant Nutritional Physiological Phenomena - physiology Infant, Newborn Infants Japan Male Milk milk allergy Nutritional Status Pediatrics Protein Hydrolysates - administration & dosage Vitamin B |
| title | Low serum biotin in Japanese children fed with hydrolysate formula |
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