Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

It has been generally accepted that both natural and man‐made sources of ionizing radiation contribute to human exposure and consequently pose a possible risk to human health. However, accumulating evidence has shown that the biological effects of low‐dose radiation (LDR) are different from those of...

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Bibliographic Details
Published in:International journal of cancer 2016-11, Vol.139 (10), p.2157-2168
Main Authors: Yang, Guozi, Li, Wei, Jiang, Hongyu, Liang, Xinyue, Zhao, Yuguang, Yu, Dehai, Zhou, Lei, Wang, Guanjun, Tian, Huimin, Han, Fujun, Cai, Lu, Cui, Jiuwei
Format: Article
Language:English
Subjects:
adaptive response
Animals
Cancer
Cell proliferation
Cell Proliferation - radiation effects
Dose-Response Relationship, Radiation
hormesis
Hormesis - radiation effects
Humans
Immune System - radiation effects
Ionizing radiation
low‐dose radiation
Medical research
Neoplasms - immunology
Neoplasms - radiotherapy
Radiation therapy
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Summary:It has been generally accepted that both natural and man‐made sources of ionizing radiation contribute to human exposure and consequently pose a possible risk to human health. However, accumulating evidence has shown that the biological effects of low‐dose radiation (LDR) are different from those of high‐dose radiation. LDR can stimulate proliferation of normal cells and activate their defense systems, while these biological effects are not observed in some cancer cell types. Although there is still no concordance on this matter, the fact that LDR has the potential to enhance the effects of cancer therapeutics and reduce the toxic side effects of anti‐cancer therapy has garnered significant interest. Here, we provide an overview of the current knowledge regarding the experimental data detailing the different responses of normal and cancer tissues to LDR, the underlying mechanisms, and its significance in clinical application.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.30235