Neonatal infection with a milk-borne virus is independent of beta 7 integrin- and L-selectin-expressing lymphocytes

Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta 7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-media...

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Bibliographic Details
Published in:European journal of immunology 2002-04, Vol.32 (4), p.945-956
Main Authors: Czarneski, J, Berguer, P, Bekinschtein, P, Kim, D C, Hakimpour, P, Wagner, N, Nepomnaschy, I, Piazzon, I, Ross, SR
Format: Article
Language:English
Subjects:
L-selectin
Mouse mammary tumor virus
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Summary:Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta 7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta 7 and beta 1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta 7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
ISSN:0014-2980
DOI:10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0.CO;2-M