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Growth and micronutrient disturbances in stable, HIV-infected children in Cape Town
This prospective study of 60 stable, HIV-infected children in an economically deprived setting was designed to document anthropometric and micronutrient disturbances. Investigations included CD4+ counts, anthropometry and plasma levels of albumin, transthyretin, retinol-binding protein (RBP), vitami...
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| Published in: | Annals of tropical paediatrics 2002-03, Vol.22 (1), p.19-23 |
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| cites | cdi_FETCH-LOGICAL-c414t-26368abefb7840974fe44c74790415208248a689469d65bd856f68b2d2b797a3 |
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| container_title | Annals of tropical paediatrics |
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| creator | Eley, Brian S. Sive, Alan A. Abelse, Lisa Kossew, Glynis Cooper, Margaret Hussey, Gregory D. |
| description | This prospective study of 60 stable, HIV-infected children in an economically deprived setting was designed to document anthropometric and micronutrient disturbances. Investigations included CD4+ counts, anthropometry and plasma levels of albumin, transthyretin, retinol-binding protein (RBP), vitamins A, B
6
, E and B
12
, and folate, zinc and copper. The median age was 25 months. Thirty-two per cent had mild, 48% moderate and 20% severe clinical features, and 80% were moderately or severely immunosuppressed. Twenty-eight per cent had a weight Z-score |
| doi_str_mv | 10.1179/027249302125000111 |
| format | article |
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6
, E and B
12
, and folate, zinc and copper. The median age was 25 months. Thirty-two per cent had mild, 48% moderate and 20% severe clinical features, and 80% were moderately or severely immunosuppressed. Twenty-eight per cent had a weight Z-score <-2.0 and 58% a height Z-score <-2.0. Many children had micronutrient deficiencies: albumin (70%), transthyretin (100%), RBP (85%), vitamins A (80%), B
6
(37%), E (37%) and B
12
(5%), zinc (20%) and copper (25%). Sixty-two per cent had two or more trace element or vitamin deficiencies. There was a weak association between micronutrient status and disease status. Micronutrient concentrations did not correlate with chronological age, height-for-age or weight-for-age. CRP was elevated in 53% but did not correlate with any of the micronutrient concentrations. Micronutrient deficiencies were more common and micronutrient concentrations lower in children over 24 months of age.</description><identifier>ISSN: 0272-4936</identifier><identifier>EISSN: 1465-3281</identifier><identifier>DOI: 10.1179/027249302125000111</identifier><identifier>PMID: 11926045</identifier><identifier>CODEN: ATPAD9</identifier><language>eng</language><publisher>Leeds: Taylor & Francis</publisher><subject>Anthropometry ; Biological and medical sciences ; C-Reactive Protein - analysis ; CD4 antigen ; CD4 Lymphocyte Count ; Child, Preschool ; Female ; Growth Disorders - blood ; Growth Disorders - complications ; HIV Infections - blood ; HIV Infections - complications ; HIV Infections - immunology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immune Tolerance ; Infant ; Infectious diseases ; Male ; Medical sciences ; Micronutrients - blood ; Poverty ; Prospective Studies ; retinol-binding protein ; South Africa ; transthyretin ; Tropical medicine ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Vitamin B12 ; Vitamin B6</subject><ispartof>Annals of tropical paediatrics, 2002-03, Vol.22 (1), p.19-23</ispartof><rights>2002 The Liverpool School of Tropical Medicine 2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-26368abefb7840974fe44c74790415208248a689469d65bd856f68b2d2b797a3</citedby><cites>FETCH-LOGICAL-c414t-26368abefb7840974fe44c74790415208248a689469d65bd856f68b2d2b797a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13546153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11926045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eley, Brian S.</creatorcontrib><creatorcontrib>Sive, Alan A.</creatorcontrib><creatorcontrib>Abelse, Lisa</creatorcontrib><creatorcontrib>Kossew, Glynis</creatorcontrib><creatorcontrib>Cooper, Margaret</creatorcontrib><creatorcontrib>Hussey, Gregory D.</creatorcontrib><title>Growth and micronutrient disturbances in stable, HIV-infected children in Cape Town</title><title>Annals of tropical paediatrics</title><addtitle>Ann Trop Paediatr</addtitle><description>This prospective study of 60 stable, HIV-infected children in an economically deprived setting was designed to document anthropometric and micronutrient disturbances. Investigations included CD4+ counts, anthropometry and plasma levels of albumin, transthyretin, retinol-binding protein (RBP), vitamins A, B
6
, E and B
12
, and folate, zinc and copper. The median age was 25 months. Thirty-two per cent had mild, 48% moderate and 20% severe clinical features, and 80% were moderately or severely immunosuppressed. Twenty-eight per cent had a weight Z-score <-2.0 and 58% a height Z-score <-2.0. Many children had micronutrient deficiencies: albumin (70%), transthyretin (100%), RBP (85%), vitamins A (80%), B
6
(37%), E (37%) and B
12
(5%), zinc (20%) and copper (25%). Sixty-two per cent had two or more trace element or vitamin deficiencies. There was a weak association between micronutrient status and disease status. Micronutrient concentrations did not correlate with chronological age, height-for-age or weight-for-age. CRP was elevated in 53% but did not correlate with any of the micronutrient concentrations. Micronutrient deficiencies were more common and micronutrient concentrations lower in children over 24 months of age.</description><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - analysis</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Growth Disorders - blood</subject><subject>Growth Disorders - complications</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Micronutrients - blood</subject><subject>Poverty</subject><subject>Prospective Studies</subject><subject>retinol-binding protein</subject><subject>South Africa</subject><subject>transthyretin</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Vitamin B12</subject><subject>Vitamin B6</subject><issn>0272-4936</issn><issn>1465-3281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqF0E9r2zAYx3ExWtq02xvYofjSneZOj_7rsEMJWxII7LCwq5EtmarYcibJhLz72iSlh8J20uXzexBfhD4DfgCQ-hsmkjBNMQHCMcYA8AEtgAleUqLgAi1mUE5CXKOblJ5noyS5QtcAmgjM-AL9XsXhkJ8KE2zR-yYOYczRu5AL61MeY21C41LhQ5GyqTv3tVhv_pQ-tK7JzhbNk-9sdGEGS7N3xW44hI_osjVdcp_O7y3a_fyxW67L7a_VZvm4LRsGLJdEUKFM7dpaKoa1ZK1jrJFMasyAE6wIU0YozYS2gtdWcdEKVRNLaqmlobfoy-nsPg5_R5dy1fvUuK4zwQ1jqiRwzoHr_0JQlAKQGZITnDqkFF1b7aPvTTxWgKs5efU--TS6O18f697Zt8m58QTuz8CkxnRtnJL69OYoZwI4ndz3k5vqDrE3hyF2tsrm2A3xdUT_8ZEX9eyZfQ</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Eley, Brian S.</creator><creator>Sive, Alan A.</creator><creator>Abelse, Lisa</creator><creator>Kossew, Glynis</creator><creator>Cooper, Margaret</creator><creator>Hussey, Gregory D.</creator><general>Taylor & Francis</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Growth and micronutrient disturbances in stable, HIV-infected children in Cape Town</title><author>Eley, Brian S. ; Sive, Alan A. ; Abelse, Lisa ; Kossew, Glynis ; Cooper, Margaret ; Hussey, Gregory D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-26368abefb7840974fe44c74790415208248a689469d65bd856f68b2d2b797a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - analysis</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Growth Disorders - blood</topic><topic>Growth Disorders - complications</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Micronutrients - blood</topic><topic>Poverty</topic><topic>Prospective Studies</topic><topic>retinol-binding protein</topic><topic>South Africa</topic><topic>transthyretin</topic><topic>Tropical medicine</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Vitamin B12</topic><topic>Vitamin B6</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eley, Brian S.</creatorcontrib><creatorcontrib>Sive, Alan A.</creatorcontrib><creatorcontrib>Abelse, Lisa</creatorcontrib><creatorcontrib>Kossew, Glynis</creatorcontrib><creatorcontrib>Cooper, Margaret</creatorcontrib><creatorcontrib>Hussey, Gregory D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of tropical paediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eley, Brian S.</au><au>Sive, Alan A.</au><au>Abelse, Lisa</au><au>Kossew, Glynis</au><au>Cooper, Margaret</au><au>Hussey, Gregory D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth and micronutrient disturbances in stable, HIV-infected children in Cape Town</atitle><jtitle>Annals of tropical paediatrics</jtitle><addtitle>Ann Trop Paediatr</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>22</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0272-4936</issn><eissn>1465-3281</eissn><coden>ATPAD9</coden><abstract>This prospective study of 60 stable, HIV-infected children in an economically deprived setting was designed to document anthropometric and micronutrient disturbances. Investigations included CD4+ counts, anthropometry and plasma levels of albumin, transthyretin, retinol-binding protein (RBP), vitamins A, B
6
, E and B
12
, and folate, zinc and copper. The median age was 25 months. Thirty-two per cent had mild, 48% moderate and 20% severe clinical features, and 80% were moderately or severely immunosuppressed. Twenty-eight per cent had a weight Z-score <-2.0 and 58% a height Z-score <-2.0. Many children had micronutrient deficiencies: albumin (70%), transthyretin (100%), RBP (85%), vitamins A (80%), B
6
(37%), E (37%) and B
12
(5%), zinc (20%) and copper (25%). Sixty-two per cent had two or more trace element or vitamin deficiencies. There was a weak association between micronutrient status and disease status. Micronutrient concentrations did not correlate with chronological age, height-for-age or weight-for-age. CRP was elevated in 53% but did not correlate with any of the micronutrient concentrations. Micronutrient deficiencies were more common and micronutrient concentrations lower in children over 24 months of age.</abstract><cop>Leeds</cop><pub>Taylor & Francis</pub><pmid>11926045</pmid><doi>10.1179/027249302125000111</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of tropical paediatrics, 2002-03, Vol.22 (1), p.19-23 |
| issn | 0272-4936 1465-3281 |
| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Anthropometry Biological and medical sciences C-Reactive Protein - analysis CD4 antigen CD4 Lymphocyte Count Child, Preschool Female Growth Disorders - blood Growth Disorders - complications HIV Infections - blood HIV Infections - complications HIV Infections - immunology Human immunodeficiency virus Human viral diseases Humans Immune Tolerance Infant Infectious diseases Male Medical sciences Micronutrients - blood Poverty Prospective Studies retinol-binding protein South Africa transthyretin Tropical medicine Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Vitamin B12 Vitamin B6 |
| title | Growth and micronutrient disturbances in stable, HIV-infected children in Cape Town |
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