Corticotropin-Releasing Hormone: An Autocrine Hormone That Promotes Lipogenesis in Human Sebocytes

Sebaceous glands may be involved in a pathway conceptually similar to that of the hypothalamic-pituitary-adrenal (HPA) axis. Such a pathway has been described and may occur in human skin and lately in the sebaceous glands because they express neuropeptide receptors. Corticotropin-releasing hormone (...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-05, Vol.99 (10), p.7148-7153
Main Authors: Zouboulis, Christos C., Seltmann, Holger, Hiroi, Naoki, Chen, WenChieh, Young, Maggie, Oeff, Marina, Scherbaum, Werner A., Orfanos, Constantin E., McCann, Samuel M., Bornstein, Stefan R.
Format: Article
Language:English
Subjects:
3-Hydroxysteroid Dehydrogenases - genetics
Biological Sciences
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Division
Cell growth
Cell Line
Cell Survival
Cells
Corticotropin-Releasing Hormone - genetics
Corticotropin-Releasing Hormone - metabolism
Corticotropin-releasing hormone-binding protein
Gene Expression
Growth Hormone - pharmacology
Hormonal regulation
Hormones
Humans
Interleukin-1 - pharmacology
Interleukin-8 - metabolism
Lipids
Lipids - biosynthesis
Lipogenesis
Messenger RNA
Proteins
Receptors
Receptors, Corticotropin-Releasing Hormone - genetics
Receptors, Corticotropin-Releasing Hormone - metabolism
Reverse transcriptase polymerase chain reaction
RNA, Messenger - metabolism
Sebaceous Glands - cytology
Sebaceous Glands - metabolism
sebocytes
seborrhea
Skin
Studies
Testosterone
Testosterone - pharmacology
Up-Regulation
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