Femtosecond laser-assisted LASIK versus PRK for high myopia: comparison of 18-month visual acuity and quality

• Published in: International ophthalmology 2017-08, Vol.37 (4), p.995-1001
• Main Authors: Hashemi, Hassan, Ghaffari, Reza, Miraftab, Mohammad, Asgari, Soheila
• Format: Article
• Language: English
• Subjects: Aberration; Ablation; Acuity; Adult; Cornea; Errors; Eye (anatomy); Female; Follow-Up Studies; Humans; Keratomileusis, Laser In Situ - methods; Lasers; Lasers, Excimer - therapeutic use; Male; Medicine; Medicine & Public Health; Mitomycin C; Myopia; Myopia, Degenerative - physiopathology; Myopia, Degenerative - surgery; Ophthalmology; Original Paper; Photorefractive Keratectomy - methods; Photorefractivity; Prospective Studies; Refraction; Refraction, Ocular - physiology; Time Factors; Visual Acuity
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-016-0364-7

Purpose To compare 18-month outcomes between femtosecond laser-assisted LASIK (femto-LASIK) and photorefractive keratectomy with mitomycin-C (PRK-MMC) for myopia of more than 7.0 D in terms of visual acuity and quality. Methods In this comparative nonrandomized clinical trial, 60 eyes from 30 patients (30 eyes in each group) were enrolled. The two procedures were compared in terms of 18-month changes in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent, ocular and corneal higher order aberrations (HOAs), and contrast sensitivity (CS). Results Mean myopia was −8.65 ± 1.51 and −8.04 ± 1.70 D ( P  = 0.149) and mean ablation depth was 109.37 ± 9.07 and 105.09 ± 12.59 µm ( P  = 0.138), in the femto-LASIK and PRK-MMC groups, respectively. Baseline parameters were not significantly different between the two groups (all P  > 0.05). At 18 months postoperatively, 75 % in the femto-LASIK, versus 57.1 % in the PRK-MMC group, had 20/20 UDVA ( P  = 0.017). CDVA remained similarly unchanged in both groups ( P  = 0.616). No case had residual refractive error more than 1.0 D in the femto-LASIK group, while 33.5 % in the other group had more than 1.0 D residual error ( P  = 0.390). Changes in corneal HOA were not significantly different between the two groups ( P  = 0.260). Cases in the femto-LASIK group showed more increase in ocular HOA ( P  = 0.032) and coma ( P  = 0.083, power = 72 %). CS remained similarly unchanged in all spatial frequencies in both groups (all P  > 0.05). Conclusion Although femto-LASIK induces more HOA compared to PRK-MMC, considering outcomes in terms of 20/20 UDVA, residual refractive error, and CS stability, femto-LASIK provides more favorable results than PRK-MMC in high myopia.