New influenza A(H7N7) viruses detected in live poultry markets in China

Abstract H7N7 avian influenza viruses have been widely detected in wild birds and domestic poultry since they were first detected in chickens in Italy in 1902. They can occasionally transmit to humans. Here, we isolated six H7N7 viruses in live poultry markets during routine surveillance from 2010 t...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2016-12, Vol.499, p.165-169
Main Authors: Cui, Pengfei, Deng, Guohua, Shi, Jianzhong, Kong, Huihui, Liu, Liling, Guan, Yuntao, Suzuki, Yasuo, Chen, Hualan
Format: Article
Language:English
Subjects:
Animals
Avian influenza virus
China - epidemiology
Genotype
H7N7
Humans
Infectious Disease
Influenza A Virus, H7N7 Subtype - classification
Influenza A Virus, H7N7 Subtype - genetics
Influenza A Virus, H7N7 Subtype - isolation & purification
Influenza in Birds - epidemiology
Influenza in Birds - virology
Live poultry market
Mice
Orthomyxoviridae Infections - virology
Phylogeny
Poultry - virology
Public Health Surveillance
Receptors, Virus - metabolism
Viral Proteins - genetics
Virus Attachment
Virus Replication
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Summary:Abstract H7N7 avian influenza viruses have been widely detected in wild birds and domestic poultry since they were first detected in chickens in Italy in 1902. They can occasionally transmit to humans. Here, we isolated six H7N7 viruses in live poultry markets during routine surveillance from 2010 to 2013. Sequences analysis revealed that these viruses are reassortants bearing genes of H3N8, H7N3, H7N7, and H10N7 influenza viruses detected in wild birds and ducks, and can be categorized into three genotypes (A, B, and C). All six viruses bound to both human-type and avian-type receptors. The viruses in genotype B and C could replicate efficiently in the lungs and nasal turbinates of mice without prior adaptation, and the genotype C virus also replicated in the brain of two of three mice tested. It is important to continue to monitor the evolution of H7N7 viruses and to evaluate their potential to cause human infections.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2016.06.015