Parasites, microbiota and metabolic disease

Summary Recent years have witnessed a dramatic increase in diseases that are ascribed to alter metabolism eventually resulting in conditions including obesity, type‐2 diabetes (T2D), cardiovascular disease and metabolic syndrome (MetS). Of the many factors to which this rise has been attributed, inc...

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Bibliographic Details
Published in:Parasite immunology 2017-05, Vol.39 (5), p.n/a
Main Authors: Bhattacharjee, S., Kalbfuss, N., Prazeres da Costa, C.
Format: Article
Language:English
Subjects:
Animals
cardiovascular disease
diabetes
Diabetes mellitus
Diet
Humans
Inflammation
Inflammation - microbiology
Intestinal microflora
Metabolic Diseases - microbiology
Metabolic Diseases - parasitology
Metabolic syndrome
Metabolism
Microbiota
obesity
Parasites
Parasitic Diseases - microbiology
Physical activity
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Summary:Summary Recent years have witnessed a dramatic increase in diseases that are ascribed to alter metabolism eventually resulting in conditions including obesity, type‐2 diabetes (T2D), cardiovascular disease and metabolic syndrome (MetS). Of the many factors to which this rise has been attributed, including diet, physical activity and inflammation, several studies have correlated these disease states with alterations in gut microbiota. Simultaneously, studies have demonstrated the ability of parasites to alter microbial communities within their shared niche, leading to alterations in inflammatory processes. However, very few reports have addressed how these changes to the microbiome may be a mechanism by which parasites influence not only inflammation but also metabolic states. In this review, we attempt to draw parallels between the three capacious topics and examine the interrelationship between them.
ISSN:0141-9838
1365-3024
DOI:10.1111/pim.12390