Rotational thromboelastometry can detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis

Background & Aims Patients with progressive liver disease exhibit complex coagulation disorders. Factor XIII plays a crucial role in the last steps of haemostasis, and its deficiency is associated with an increased incidence of bleeding diathesis. However, current conventional coagulation tests...

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Bibliographic Details
Published in:Liver international 2017-04, Vol.37 (4), p.562-568
Main Authors: Bedreli, Sotiria, Sowa, Jan‐Peter, Malek, Saraa, Blomeyer, Sandra, Katsounas, Antonios, Gerken, Guido, Saner, Fuat H., Canbay, Ali
Format: Article
Language:English
Subjects:
Bleeding
Cirrhosis
Coagulation
Coagulation factors
Complications
Disease Susceptibility
Disorders
factor XIII
Factor XIII Deficiency - diagnosis
Factor XIII Deficiency - etiology
Female
Fibrinogen
Germany
Hemorrhage
Hemorrhage - etiology
Humans
Incidence
International Normalized Ratio
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Liver diseases
Lysis
Male
Middle Aged
Patients
Platelet Count
Predictive Value of Tests
Retrospective Studies
rotational thromboelastometry
ROTEM
Thrombelastography - methods
Thromboplastin
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Summary:Background & Aims Patients with progressive liver disease exhibit complex coagulation disorders. Factor XIII plays a crucial role in the last steps of haemostasis, and its deficiency is associated with an increased incidence of bleeding diathesis. However, current conventional coagulation tests cannot detect factor XIII deficiency. In this study, we examined factor XIII activity and the ability of rotational thromboelastometry to detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis. Methods We retrospectively studied 74 patients with cirrhosis, comparing the results of conventional coagulation tests (international normalized ratio, activated partial thromboplastin time, platelet count, fibrinogen level), rotational thromboelastometry, factor XIII activity and clinical scores. Results Patients with cirrhosis exhibited reduced factor XIII activity. Factor XIII activity was positively correlated with conventional coagulation parameters and rotational thromboelastometry values, such as maximum clot formation (MCF)extem (r=.48, P
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13254