Cognitive fatigue is associated with reduced anterior internal capsule integrity in veterans with history of mild to moderate traumatic brain injury

• Published in: Brain imaging and behavior 2017-10, Vol.11 (5), p.1548-1554
• Main Authors: Clark, Alexandra L., Delano-Wood, Lisa, Sorg, Scott F., Werhane, Madeleine L., Hanson, Karen L., Schiehser, Dawn M.
• Format: Article
• Language: English
• Subjects: Adult; Adults; Arousal; Biomedical and Life Sciences; Biomedicine; Brain; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - diagnostic imaging; Brain Injuries, Traumatic - pathology; Brain Injuries, Traumatic - psychology; Brief Communication; Cingulum; Cognitive ability; Cohort Studies; Corpus callosum; Cortex; Diffusion Tensor Imaging; Disruption; Fatigue; Female; Head injuries; Humans; Integrity; Internal Capsule - diagnostic imaging; Internal Capsule - pathology; Linear Models; Magnetic Resonance Imaging; Male; Medical imaging; Mental Fatigue - diagnostic imaging; Mental Fatigue - etiology; Mental Fatigue - pathology; Neuroimaging; Neurology; Neuropsychology; Neuroradiology; Neurosciences; Psychiatric Status Rating Scales; Psychiatry; Severity of Illness Index; Substantia alba; Surveys and Questionnaires; Traumatic brain injury; Veterans; White Matter - diagnostic imaging; White Matter - pathology
• ISSN: 1931-7557; 1931-7565
• DOI: 10.1007/s11682-016-9594-6

No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Controls [VCs] = 25]) with and without history of mmTBI underwent structural 3T DTI scans and completed questionnaires related to cognitive fatigue and psychiatric symptoms. Tractography was employed on six regions of interest, including the anterior and posterior limbs of the internal capsule; genu; body and splenium of the corpus callosum; and cingulum bundle. Group analyses revealed that those with history of mmTBI displayed significantly greater levels of cognitive fatigue relative to those with no history of head injury ( p  = .02). Within the mmTBI group, independent of psychiatric symptoms, decreased white matter microstructural integrity of the left anterior internal capsule was associated with greater levels of cognitive fatigue ( p  = .01). Results show that the subjective experience of cognitive fatigue following neurotrauma may be linked to the disruption of striato-thalamo-cortical tracts that are important in mediating arousal and higher-order cognitive processes. These findings build upon those from existing functional neuroimaging studies in those with history of TBI, providing further evidence for the neural basis of cognitive fatigue in head injured adults.