Corticomuscular Coherence: a Novel Tool to Assess the Pyramidal Tract Dysfunction in Spinocerebellar Ataxia Type 2

Clinical signs of corticospinal tract dysfunction are a common feature of spinocerebellar ataxia type 2 (SCA2) patients. The objective of this study is to assess dysfunction of the corticospinal tract in SCA2 using corticomuscular coherence. Testing corticomuscular coherence and rating of ataxia sev...

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Bibliographic Details
Published in:Cerebellum (London, England) England), 2017-04, Vol.16 (2), p.602-606
Main Authors: Velázquez-Pérez, Luis, Tünnerhoff, Johannes, Rodríguez-Labrada, Roberto, Torres-Vega, Reidenis, Belardinelli, Paolo, Medrano-Montero, Jacqueline, Peña-Acosta, Arnoy, Canales-Ochoa, Nalia, Vázquez-Mojena, Yaimeé, González-Zaldivar, Yanetza, Auburger, Georg, Ziemann, Ulf
Format: Article
Language:English
Subjects:
Adult
Aged
Ataxin-2 - genetics
Biomedical and Life Sciences
Biomedicine
Electroencephalography
Electromyography
Female
Humans
Lower Extremity - physiopathology
Male
Middle Aged
Muscle, Skeletal - physiopathology
Mutation
Neural Conduction - physiology
Neurobiology
Neurology
Neurosciences
Pyramidal Tracts - physiopathology
Severity of Illness Index
Short Report
Signal Processing, Computer-Assisted
Spinocerebellar Ataxias - diagnosis
Spinocerebellar Ataxias - genetics
Spinocerebellar Ataxias - physiopathology
Transcranial Magnetic Stimulation
Upper Extremity - physiopathology
Young Adult
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Summary:Clinical signs of corticospinal tract dysfunction are a common feature of spinocerebellar ataxia type 2 (SCA2) patients. The objective of this study is to assess dysfunction of the corticospinal tract in SCA2 using corticomuscular coherence. Testing corticomuscular coherence and rating of ataxia severity and non-ataxia symptoms were performed in 19 SCA2 patients and 24 age-matched controls. Central motor conduction times (CMCT) to upper and lower right limbs were obtained for the SCA2 group using Transcraneal magnetic stimulation (TMS). SCA2 patients exhibited a significant reduction of corticomuscular coherence for lower limbs, but not for upper limbs. This difference remained significant, even when excluding those individuals with clinical signs of corticospinal tract dysfunction. Corticomuscular coherence for lower limbs correlated inversely with CMCT to tibialis anterior muscle. Corticomuscular coherence could be a valuable electrophysiological tool to assess the corticospinal tract involvement in SCA2, even in the absence of clinical signs of corticospinal tract dysfunction.
ISSN:1473-4222
1473-4230
DOI:10.1007/s12311-016-0827-4