Copper-Mediated Oxidative Functionalization of C(sp 3 )-H Bonds with Isoquinolines: Two-Step Synthesis of 5-Oxaprotoberberinones

A copper-mediated oxidative functionalization of C(sp )-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure pr...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-11, Vol.81 (22), p.11162-11167
Main Authors: Wang, Dingyi, Zhang, Rongxing, Deng, Ruihong, Lin, Sen, Guo, Shengmei, Yan, Zhaohua
Format: Article
Language:English
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Summary:A copper-mediated oxidative functionalization of C(sp )-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure provides a simple method to afford 5-oxaprotoberberinones and their derivatives in two steps.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b02145