The Role of Exercise in a Weight-Loss Program on Clinical Control in Obese Adults with Asthma. A Randomized Controlled Trial

Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated. To examine the effect of exercise training in a weight-loss...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195 (1), p.32-42
Main Authors: Freitas, Patricia D, Ferreira, Palmira G, Silva, Aline G, Stelmach, Rafael, Carvalho-Pinto, Regina M, Fernandes, Frederico L A, Mancini, Marcio C, Sato, Maria N, Martins, Milton A, Carvalho, Celso R F
Format: Article
Language:English
Subjects:
Asthma - complications
Asthma - physiopathology
Asthma - therapy
Biomarkers - blood
Caloric Restriction - methods
Exercise
Female
Humans
Inflammation - blood
Inflammation - physiopathology
Lung - physiopathology
Male
Middle Aged
Muscle Strength
Obesity - complications
Obesity - therapy
Quality of Life
Resistance Training
Respiratory Function Tests
Weight Reduction Programs - methods
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Summary:Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated. To examine the effect of exercise training in a weight-loss program on asthma control, quality of life, inflammatory biomarkers, and lung function. Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program plus exercise (WL + E group, n = 28) or a weight-loss program plus sham (WL + S group, n = 27), where the weight-loss program included nutrition (caloric restriction) and psychological therapies. The WL + E group incorporated aerobic and resistance muscle training, whereas the WL + S group incorporated breathing and stretching exercises. The primary outcome was clinical improvement in asthma control over 3 months. Secondary outcomes included quality of life, lung function, body composition, aerobic capacity, muscle strength, and inflammatory/antiinflammatory biomarkers. After 3 months, 51 patients were analyzed. Compared with the WL + S group, the WL + E group demonstrated improved clinical control scores (median [25th to 75th percentile], -0.7 [-1.3 to -0.3] vs. -0.3 [-0.9 to 0.4]; P = 0.01) and greater weight loss (mean ± SD, -6.8% ± 3.5 vs. -3.1% ± 2.6; P 
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201603-0446OC