New adverse obstetrics outcomes associated with endometriosis: a retrospective cohort study

Purpose The main aim of this study was to evaluate the incidence of endometriosis and intrahepatic cholestasis (ICP) and induction of labor in pregnant women with endometriosis compared with women without endometriosis. The secondary aim was to confirm increased incidence of already known endometrio...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2017, Vol.295 (1), p.141-151
Main Authors: Mannini, Luca, Sorbi, Flavia, Noci, Ivo, Ghizzoni, Viola, Perelli, Federica, Di Tommaso, Mariarosaria, Mattei, Alberto, Fambrini, Massimiliano
Format: Article
Language:English
Subjects:
Adult
Cholestasis, Intrahepatic - complications
Cohort analysis
Cohort Studies
Endocrinology
Endometriosis
Endometriosis - complications
Female
General Gynecology
Gynecology
Health risk assessment
Human Genetics
Humans
Incidence
Induced labor
Infant, Newborn
Medicine
Medicine & Public Health
Obstetrics
Obstetrics/Perinatology/Midwifery
Placenta
Pregnancy
Pregnancy complications
Pregnancy Complications - etiology
Premature birth
Retrospective Studies
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Summary:Purpose The main aim of this study was to evaluate the incidence of endometriosis and intrahepatic cholestasis (ICP) and induction of labor in pregnant women with endometriosis compared with women without endometriosis. The secondary aim was to confirm increased incidence of already known endometriosis-related pregnancy complications in these patients. Methods This is a retrospective cohort study performed at a tertiary hospital between January 2009 and December 2014 to compare obstetrics outcome between women with endometriosis and women without endometriosis. Pregnant patients with endometriosis were included in the study group. Patients were divided in the following subgroups: patients with deep infiltrating endometriosis (DIE subgroup) and patients without deep infiltrating endometriosis (non-DIE subgroup); patients with singleton pregnancy and spontaneous conception (subgroup A) and patients with multiple pregnancy and/or patients who underwent assisted reproductive technology (subgroup B). To form a control group, for each patient with endometriosis, two patients without endometriosis were selected as the control group by means of matched sample. Results The study population included 262 pregnant women with endometriosis and 524 controls. Patients of the study population had significantly increased risks of placenta praevia ( p  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-016-4222-7