Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines

The highly diastereo- and enantioselective Mannich addition/cyclisation reaction of α-substituted isocyanoacetate ester pronucleophiles and (hetero)aryl and alkyl methyl ketone-derived ketimines using a silver acetate and a cinchona-derived amino phosphine binary catalyst system is reported.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (70), p.10632-10635
Main Authors: de la Campa, Raquel, Gammack Yamagata, Adam D, Ortín, Irene, Franchino, Allegra, Thompson, Amber L, Odell, Barbara, Dixon, Darren J
Format: Article
Language:English
Subjects:
Acetates
Binary systems (materials)
Catalysis
Catalysts
Esters
Imines
Phosphines
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Summary:The highly diastereo- and enantioselective Mannich addition/cyclisation reaction of α-substituted isocyanoacetate ester pronucleophiles and (hetero)aryl and alkyl methyl ketone-derived ketimines using a silver acetate and a cinchona-derived amino phosphine binary catalyst system is reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc04132a