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Self-Immolative Linkers as Caps for the Design of Gated Silica Mesoporous Supports

A new hybrid material based on sulforhodamine B dye‐loaded silica mesoporous nanoparticles capped with a self‐immolative gate has been synthesized and characterized. The gated material's controlled release behavior is monitored under different pH conditions. Under acidic and neutral conditions,...

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Bibliographic Details
Published in:Chemistry : a European journal 2016-09, Vol.22 (40), p.14126-14130
Main Authors: Juárez, L. Alberto, Añón, Elena, Giménez, Cristina, Sancenón, Félix, Martínez-Máñez, Ramón, Costero, Ana M., Gaviña, Pablo, Parra, Margarita, Bernardos, Andrea
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Language:English
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Summary:A new hybrid material based on sulforhodamine B dye‐loaded silica mesoporous nanoparticles capped with a self‐immolative gate has been synthesized and characterized. The gated material's controlled release behavior is monitored under different pH conditions. Under acidic and neutral conditions, a low level of dye release is detected. However, at slightly basic pH, significant dye release occurs owing to deprotonation of the phenol moiety in the capping molecule, which results in its disassembly. Immolative cocktail: The synthesis, characterization, and controlled release behavior of a new hybrid material based on dye‐loaded silica mesoporous nanoparticles capped with a self‐immolative gate are reported. At acidic and neutral pH, the gate remains closed leading to low levels of dye release, but at slightly basic pH, significant dye release occurs.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201602126