And I hope you like jamming too

The sorting of distinctly different cell types into specific tissue compartments has long been thought to be a problem in minimization of total free energy in immiscible fluids, wherein cell-cell adhesion, cell stiffness, and cell contraction combine to define an effective macroscopic tissue surface...

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Bibliographic Details
Published in:New journal of physics 2015-09, Vol.17 (9), p.91001
Main Authors: Tambe, Dhananjay T, Fredberg, Jeffrey J
Format: Article
Language:English
Subjects:
Adhesion
Biotechnology
cancer
Cell adhesion
Cell adhesion & migration
Density
Energy conservation
Fluid dynamics
Fluid flow
Fluids
Free energy
Jamming
Optimization
Physics
soft matter
Stiffness
Surface tension
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Summary:The sorting of distinctly different cell types into specific tissue compartments has long been thought to be a problem in minimization of total free energy in immiscible fluids, wherein cell-cell adhesion, cell stiffness, and cell contraction combine to define an effective macroscopic tissue surface tension. Pawlizak et al (2015 New J. Phys. 17 083049) now show not only that adhesion forces at interfaces unexpectedly fail to correlate with the density of adhesion molecules, but also that certain cancer cell lines unexpectedly fail to behave as a fluid, with cells becoming kinetically trapped in what might be a jammed, solid-like non-equilibrium state.
ISSN:1367-2630
1367-2630
DOI:10.1088/1367-2630/17/9/091001