Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery

• Published in: Annals of surgical oncology 2017-04, Vol.24 (4), p.1135-1142
• Main Authors: Nojiri, Takashi, Hamasaki, Toshimitsu, Inoue, Masayoshi, Shintani, Yasushi, Takeuchi, Yukiyasu, Maeda, Hajime, Okumura, Meinoshin
• Format: Article
• Language: English
• Subjects: Acute-Phase Reaction - blood; Acute-Phase Reaction - etiology; Aged; C-Reactive Protein - metabolism; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Disease-Free Survival; Female; Humans; Incidence; Leukocyte Count; Lung cancer; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local - epidemiology; Oncology; Postoperative Complications - blood; Postoperative Complications - etiology; Postoperative Period; Respiratory Tract Diseases - blood; Respiratory Tract Diseases - etiology; Surgery; Surgical Oncology; Thoracic Oncology; Time Factors
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-016-5655-8

Background Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, resulting in early cancer recurrence. We investigated the impact of postoperative cardiopulmonary complications on cancer recurrence following lung cancer surgery. Methods From a prospective database of 675 consecutive patients who underwent curative surgery for lung cancer between 2007 and 2012, the incidence of postoperative cardiopulmonary complications, white blood cell counts, and C-reactive protein levels were evaluated in the acute phase after surgery. Four patients had both cardiovascular and respiratory complications. The remaining 671 patients were divided into 3 groups: patients without cardiopulmonary complications; those with cardiovascular complications; and those with respiratory complications. The incidence of cancer recurrence was compared among the three groups. Results Postoperative cardiovascular or respiratory complications were identified in 94 (14%) or 25 (4%) patients, respectively. Postoperative white blood cell counts and C-reactive protein levels were significantly higher in those with postoperative respiratory complications than in those without. There was a significantly higher incidence of cancer recurrence in those with postoperative respiratory complications than in those without (48.0 vs. 16.8%; p