Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy

Vascular endothelial growth factor (VEGF) signaling is an important pathway in the development of diabetic retinopathy (DR). A recent report showed that leukocyte cell-derived chemotaxin 2 (LECT2) suppresses the VEGF signaling in endothelial cells. However, the clinical relevance of LECT2 in DR is u...

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Published in:Clinica chimica acta 2016-12, Vol.463, p.145-149
Main Authors: Okumura, Akinori, Unoki-Kubota, Hiroyuki, Yoshida-Hata, Natsuyo, Yamamoto-Honda, Ritsuko, Yamashita, Shigeo, Iwata, Minoru, Tobe, Kazuyuki, Kajio, Hiroshi, Noda, Mitsuhiko, Katai, Naomichi, Yamagoe, Satoshi, Kaburagi, Yasushi
Format: Article
Language:English
Subjects:
Adult
Aged
Diabetes Mellitus, Type 2 - blood
Diabetic retinopathy
Diabetic Retinopathy - blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Intercellular Signaling Peptides and Proteins - blood
Leukocyte cell-derived chemotaxin 2
Male
Middle Aged
Type 2 diabetes mellitus
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Summary:Vascular endothelial growth factor (VEGF) signaling is an important pathway in the development of diabetic retinopathy (DR). A recent report showed that leukocyte cell-derived chemotaxin 2 (LECT2) suppresses the VEGF signaling in endothelial cells. However, the clinical relevance of LECT2 in DR is unknown. This study aimed to investigate serum LECT2 levels and the presence of DR. The study included 230 people with type 2 diabetes mellitus (DM), 95 with DR and 135 without DR. Serum LECT2 levels were measured using an enzyme-linked immunosorbent assay. Data were evaluated using Spearman's rank correlation, univariate and multivariate logistic regression. Serum LECT2 levels were significantly lower in participants with DM having DR than in those not having DR (35.6±14.9ng/ml vs. 44.5±17.6ng/ml, P
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2016.10.031