Phosphate and Vitamin D Prevent Periodontitis in X-Linked Hypophosphatemia

X-linked hypophosphatemia (XLH) is a rare genetic skeletal disease where increased phosphate wasting in the kidney leads to hypophosphatemia and prevents normal mineralization of bone and dentin. Here, we examined the periodontal status of 34 adults with XLH and separated them according to the treat...

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Bibliographic Details
Published in:Journal of dental research 2017-04, Vol.96 (4), p.388-395
Main Authors: Biosse Duplan, M., Coyac, B.R., Bardet, C., Zadikian, C., Rothenbuhler, A., Kamenicky, P., Briot, K., Linglart, A., Chaussain, C.
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Attachment
Bone growth
Bones
Case-Control Studies
Cementum
Children
Defects
Dental cement
Dentin
Dentistry
Enamel
Familial Hypophosphatemic Rickets - complications
Familial Hypophosphatemic Rickets - diagnostic imaging
Familial Hypophosphatemic Rickets - drug therapy
Female
Gum disease
Humans
Hypophosphatemia
Hypoplasia
Immunohistochemistry
Male
Metabolic disorders
Middle Aged
Mineralization
Odontology
Patients
Periodontitis
Periodontitis - diagnostic imaging
Periodontitis - prevention & control
Phosphates - therapeutic use
Prospective Studies
Radiography, Panoramic
Supplements
Teeth
Treatment Outcome
Vitamin D
Vitamin D - therapeutic use
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Summary:X-linked hypophosphatemia (XLH) is a rare genetic skeletal disease where increased phosphate wasting in the kidney leads to hypophosphatemia and prevents normal mineralization of bone and dentin. Here, we examined the periodontal status of 34 adults with XLH and separated them according to the treatment they received for hypophosphatemia. We observed that periodontitis frequency and severity were increased in adults with XLH and that the severity varied according to the hypophosphatemia treatment. Patients who benefited from an early and continuous vitamin D and phosphate supplementation during their childhood presented less periodontal attachment loss than patients with late or incomplete supplementation. Continued hypophosphatemia treatment during adulthood further improved the periodontal health. Extracted teeth from patients with late or incomplete supplementation showed a strong acellular cementum hypoplasia when compared with age-matched healthy controls. These results show that XLH disturbs not only bone and dentin formation but also cementum and that the constitutional defect of the attachment apparatus is associated with attachment loss.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034516677528