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Clinical significance of pelvic lymph node status in prostate cancer: review of 1690 cases
To assess whether any relationship exists between the number of histologically examined lymph nodes and the detection of metastases in pelvic lymph node dissection (PLND) specimens taken from patients with radical prostatectomy (RP) for prostatic adenocarcinoma. 1690 cases of RP with PNLD were inclu...
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| Published in: | Internal and emergency medicine 2016-04, Vol.11 (3), p.399-404 |
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| cites | cdi_FETCH-LOGICAL-c405t-7481bbef7378458b05769f1209dedc8465672a716983b6599968d608f91351513 |
| container_end_page | 404 |
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| container_start_page | 399 |
| container_title | Internal and emergency medicine |
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| creator | Maccio, Livia Barresi, Valeria Domati, Federica Martorana, Eugenio Cesinaro, Anna Maria Migaldi, Mario Iachetta, Francesco Ieni, Antonio Bonetti, Luca Reggiani |
| description | To assess whether any relationship exists between the number of histologically examined lymph nodes and the detection of metastases in pelvic lymph node dissection (PLND) specimens taken from patients with radical prostatectomy (RP) for prostatic adenocarcinoma. 1690 cases of RP with PNLD were included in the study; 54 % of the patients were submitted to extended PLND (ePLND). Kaplan–Meier curves confirm the negative prognostic significance of nodal metastases on the overall patients’ survival (
P
|
| doi_str_mv | 10.1007/s11739-015-1375-5 |
| format | article |
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P
< 0.0001). Nodal metastases are significantly associated with older age of patients (
P
= 0.0466), higher pT status (
P
< 0.0001), higher Gleason score (
P
< 0.0001) and positive surgical margin (
P
< 0.0001). The frequency of nodal metastases is significantly increased in cases submitted to ePLND (
P
< 0.0001), presumably due to the significantly higher number of lymphnodes retrieved using this procedure (
P
< 0.0001). In addition, regardless of the extent of PLND procedure, entire histological examination of PLND specimens is significantly associated with a higher frequency of nodal metastases (
P
< 0.0001). When we considered only pN0 cases, 21 display adverse prognosis and died of disease during the follow-up. The number of pelvic lymphnodes examined is significantly lower in the group of patients who die of the disease compared to that of survivors (
P
= 0.0448). In addition, Kaplan–Meier analysis shows that patients with 10 or fewer examined lymphnodes have significantly shorter disease-specific survival (
P
= 0.0151). Our findings confirm the negative prognostic significance of N status in prostate cancer. We suggest the examination of a minimum number of 10 lymphnodes, together with entire PLND processing, for accurate assessment of N status.]]></description><identifier>ISSN: 1828-0447</identifier><identifier>EISSN: 1970-9366</identifier><identifier>DOI: 10.1007/s11739-015-1375-5</identifier><identifier>PMID: 26875178</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Aged ; Aged, 80 and over ; Biopsy, Needle ; Cohort Studies ; Databases, Factual ; Disease-Free Survival ; Humans ; Im - Original ; Immunohistochemistry ; Internal Medicine ; Kaplan-Meier Estimate ; Lymph Node Excision - methods ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Pelvis ; Prognosis ; Proportional Hazards Models ; Prostate-Specific Antigen - blood ; Prostatectomy - methods ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Retrospective Studies ; ROC Curve ; Survival Rate</subject><ispartof>Internal and emergency medicine, 2016-04, Vol.11 (3), p.399-404</ispartof><rights>SIMI 2016</rights><rights>Internal and Emergency Medicine is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-7481bbef7378458b05769f1209dedc8465672a716983b6599968d608f91351513</citedby><cites>FETCH-LOGICAL-c405t-7481bbef7378458b05769f1209dedc8465672a716983b6599968d608f91351513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26875178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maccio, Livia</creatorcontrib><creatorcontrib>Barresi, Valeria</creatorcontrib><creatorcontrib>Domati, Federica</creatorcontrib><creatorcontrib>Martorana, Eugenio</creatorcontrib><creatorcontrib>Cesinaro, Anna Maria</creatorcontrib><creatorcontrib>Migaldi, Mario</creatorcontrib><creatorcontrib>Iachetta, Francesco</creatorcontrib><creatorcontrib>Ieni, Antonio</creatorcontrib><creatorcontrib>Bonetti, Luca Reggiani</creatorcontrib><title>Clinical significance of pelvic lymph node status in prostate cancer: review of 1690 cases</title><title>Internal and emergency medicine</title><addtitle>Intern Emerg Med</addtitle><addtitle>Intern Emerg Med</addtitle><description><![CDATA[To assess whether any relationship exists between the number of histologically examined lymph nodes and the detection of metastases in pelvic lymph node dissection (PLND) specimens taken from patients with radical prostatectomy (RP) for prostatic adenocarcinoma. 1690 cases of RP with PNLD were included in the study; 54 % of the patients were submitted to extended PLND (ePLND). Kaplan–Meier curves confirm the negative prognostic significance of nodal metastases on the overall patients’ survival (
P
< 0.0001). Nodal metastases are significantly associated with older age of patients (
P
= 0.0466), higher pT status (
P
< 0.0001), higher Gleason score (
P
< 0.0001) and positive surgical margin (
P
< 0.0001). The frequency of nodal metastases is significantly increased in cases submitted to ePLND (
P
< 0.0001), presumably due to the significantly higher number of lymphnodes retrieved using this procedure (
P
< 0.0001). In addition, regardless of the extent of PLND procedure, entire histological examination of PLND specimens is significantly associated with a higher frequency of nodal metastases (
P
< 0.0001). When we considered only pN0 cases, 21 display adverse prognosis and died of disease during the follow-up. The number of pelvic lymphnodes examined is significantly lower in the group of patients who die of the disease compared to that of survivors (
P
= 0.0448). In addition, Kaplan–Meier analysis shows that patients with 10 or fewer examined lymphnodes have significantly shorter disease-specific survival (
P
= 0.0151). Our findings confirm the negative prognostic significance of N status in prostate cancer. We suggest the examination of a minimum number of 10 lymphnodes, together with entire PLND processing, for accurate assessment of N status.]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy, Needle</subject><subject>Cohort Studies</subject><subject>Databases, Factual</subject><subject>Disease-Free Survival</subject><subject>Humans</subject><subject>Im - Original</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Node Excision - methods</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Pelvis</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy - methods</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Survival Rate</subject><issn>1828-0447</issn><issn>1970-9366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkctKBDEQRYMovj_AjQTcuGlNJV2pxJ0MvkBwoxs3oR9pjfR0j51pxb8346iIIK5SSc69qcplbA_EEQhBxxGAlM0EYAaKMMMVtgmWRGaV1qupNtJkIs9pg23F-CQEogZaZxtSG0Igs8nuJ23oQlW0PIaHLjSp7CrP-4bPfPsSKt6-TWePvOtrz-O8mI-Rh47Phn6x8fyDHk744F-Cf13IQFuRjqOPO2ytKdrodz_XbXZ3fnY7ucyuby6uJqfXWZULnGeUGyhL35Aik6MpBZK2DUhha19XJteoSRaUfI0qNVprtam1MI0FhYCgttnh0jd19Tz6OHfTECvftkXn-zE6MIqkTXL7P0pkhQQrVUIPfqFP_Th0aZBkqFGiMCgTBUuqSj8SB9-42RCmxfDmQLhFRm6ZkUsZuUVGDpNm_9N5LKe-_lZ8hZIAuQRiuuoe_PDj6T9d3wGYdZia</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Maccio, Livia</creator><creator>Barresi, Valeria</creator><creator>Domati, Federica</creator><creator>Martorana, Eugenio</creator><creator>Cesinaro, Anna Maria</creator><creator>Migaldi, Mario</creator><creator>Iachetta, Francesco</creator><creator>Ieni, Antonio</creator><creator>Bonetti, Luca Reggiani</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Clinical significance of pelvic lymph node status in prostate cancer: review of 1690 cases</title><author>Maccio, Livia ; Barresi, Valeria ; Domati, Federica ; Martorana, Eugenio ; Cesinaro, Anna Maria ; Migaldi, Mario ; Iachetta, Francesco ; Ieni, Antonio ; Bonetti, Luca Reggiani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-7481bbef7378458b05769f1209dedc8465672a716983b6599968d608f91351513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy, Needle</topic><topic>Cohort Studies</topic><topic>Databases, Factual</topic><topic>Disease-Free Survival</topic><topic>Humans</topic><topic>Im - Original</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Node Excision - methods</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Pelvis</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy - methods</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maccio, Livia</creatorcontrib><creatorcontrib>Barresi, Valeria</creatorcontrib><creatorcontrib>Domati, Federica</creatorcontrib><creatorcontrib>Martorana, Eugenio</creatorcontrib><creatorcontrib>Cesinaro, Anna Maria</creatorcontrib><creatorcontrib>Migaldi, Mario</creatorcontrib><creatorcontrib>Iachetta, Francesco</creatorcontrib><creatorcontrib>Ieni, Antonio</creatorcontrib><creatorcontrib>Bonetti, Luca Reggiani</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Internal and emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maccio, Livia</au><au>Barresi, Valeria</au><au>Domati, Federica</au><au>Martorana, Eugenio</au><au>Cesinaro, Anna Maria</au><au>Migaldi, Mario</au><au>Iachetta, Francesco</au><au>Ieni, Antonio</au><au>Bonetti, Luca Reggiani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of pelvic lymph node status in prostate cancer: review of 1690 cases</atitle><jtitle>Internal and emergency medicine</jtitle><stitle>Intern Emerg Med</stitle><addtitle>Intern Emerg Med</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>399</spage><epage>404</epage><pages>399-404</pages><issn>1828-0447</issn><eissn>1970-9366</eissn><abstract><![CDATA[To assess whether any relationship exists between the number of histologically examined lymph nodes and the detection of metastases in pelvic lymph node dissection (PLND) specimens taken from patients with radical prostatectomy (RP) for prostatic adenocarcinoma. 1690 cases of RP with PNLD were included in the study; 54 % of the patients were submitted to extended PLND (ePLND). Kaplan–Meier curves confirm the negative prognostic significance of nodal metastases on the overall patients’ survival (
P
< 0.0001). Nodal metastases are significantly associated with older age of patients (
P
= 0.0466), higher pT status (
P
< 0.0001), higher Gleason score (
P
< 0.0001) and positive surgical margin (
P
< 0.0001). The frequency of nodal metastases is significantly increased in cases submitted to ePLND (
P
< 0.0001), presumably due to the significantly higher number of lymphnodes retrieved using this procedure (
P
< 0.0001). In addition, regardless of the extent of PLND procedure, entire histological examination of PLND specimens is significantly associated with a higher frequency of nodal metastases (
P
< 0.0001). When we considered only pN0 cases, 21 display adverse prognosis and died of disease during the follow-up. The number of pelvic lymphnodes examined is significantly lower in the group of patients who die of the disease compared to that of survivors (
P
= 0.0448). In addition, Kaplan–Meier analysis shows that patients with 10 or fewer examined lymphnodes have significantly shorter disease-specific survival (
P
= 0.0151). Our findings confirm the negative prognostic significance of N status in prostate cancer. We suggest the examination of a minimum number of 10 lymphnodes, together with entire PLND processing, for accurate assessment of N status.]]></abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>26875178</pmid><doi>10.1007/s11739-015-1375-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1828-0447 |
| ispartof | Internal and emergency medicine, 2016-04, Vol.11 (3), p.399-404 |
| issn | 1828-0447 1970-9366 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1837296989 |
| source | Springer Nature |
| subjects | Aged Aged, 80 and over Biopsy, Needle Cohort Studies Databases, Factual Disease-Free Survival Humans Im - Original Immunohistochemistry Internal Medicine Kaplan-Meier Estimate Lymph Node Excision - methods Lymph Nodes - pathology Lymph Nodes - surgery Male Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging Pelvis Prognosis Proportional Hazards Models Prostate-Specific Antigen - blood Prostatectomy - methods Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Retrospective Studies ROC Curve Survival Rate |
| title | Clinical significance of pelvic lymph node status in prostate cancer: review of 1690 cases |
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