A Magnetic Nanoparticle Stabilized Gas Containing Emulsion for Multimodal Imaging and Triggered Drug Release

ABSTRACT Purpose To develop a multimodal imaging guided and triggered drug delivery system based on a novel emulsion formulation composed of iron oxide nanoparticles, nanoscopic bubbles, and oil containing drugs. Methods Iron oxide paramagnetic nanoparticles were synthesized and modified with surfac...

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Bibliographic Details
Published in:Pharmaceutical research 2014-06, Vol.31 (6), p.1477-1484
Main Authors: Guo, Wei, Li, Diancheng, Zhu, Jia-an, Wei, Xiaohui, Men, Weiwei, Yin, Dazhi, Fan, Mingxia, Xu, Yuhong
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Chemistry, Pharmaceutical
Contrast Media - chemistry
Coumarins - administration & dosage
Coumarins - pharmacokinetics
Drug Carriers - chemistry
Drug Delivery Systems
Emulsions
Gases
Liver - metabolism
Magnetite Nanoparticles - chemistry
Medical imaging
Medical Law
Nanoparticles
Pharmacology/Toxicology
Pharmacy
Rats
Research Paper
Thiazoles - administration & dosage
Thiazoles - pharmacokinetics
Tissue Distribution
Ultrasonics
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Summary:ABSTRACT Purpose To develop a multimodal imaging guided and triggered drug delivery system based on a novel emulsion formulation composed of iron oxide nanoparticles, nanoscopic bubbles, and oil containing drugs. Methods Iron oxide paramagnetic nanoparticles were synthesized and modified with surface conjugation of polyethylenimide (PEI) or Bovine Serum Albumin (BSA). Both particles were used to disperse and stabilize oil in water emulsions containing coumarin-6 as the model drug. Sulfur hexafluoride was introduced into the oil phase to form nanoscopic bubbles inside the emulsions. The resulted gas containing emulsions were evaluated for their magnetic resonance (MR) and ultrasound (US) imaging properties. The drug release profile triggered by ultrasound was also examined. Results We have successfully prepared the highly integrated multi-component emulsion system using the surface modified iron oxide nanoparticles to stabilize the interfaces. The resulted structure had distinctive MR and US imaging properties. Upon application of ultrasound waves, the gas containing emulsion would burst and encapsulated drug could be released. Conclusion The integrated emulsion formulation was multifunctional with paramagnetic, sono-responsive and drug-carrying characteristics, which may have potential applications for disease diagnosis and imaging guided drug release.
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-014-1365-8