Pragmatic study of orlistat 60 mg on abdominal obesity

• Published in: European journal of clinical nutrition 2011-11, Vol.65 (11), p.1256-1262
• Main Authors: Thomas, E L, Makwana, A, Newbould, R, Rao, A W, Gambarota, G, Frost, G, Delafont, B, Mishra, R G, Matthews, P M, Berk, E S, Schwartz, S M, Bell, J D, Beaver, J D
• Format: Article
• Language: English
• Subjects: 631/154/436/2388; 692/699/1503/1702/393; 692/700/565/1436; Abdomen; Abdominal Fat - drug effects; Abdominal Fat - pathology; Adipose tissue; Adiposity - drug effects; Adult; Anti-Obesity Agents - administration & dosage; Anti-Obesity Agents - therapeutic use; Biological and medical sciences; Blood pressure; Body composition; Body fat; Body Mass Index; Body weight loss; Clinical Nutrition; Combined Modality Therapy; Diagnosis; Diet; Diet, Fat-Restricted; Dosage and administration; Drug therapy; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - therapeutic use; Epidemiology; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Heart rate; Humans; Hypocaloric diet; Inhibitor drugs; Internal Medicine; Lactones - administration & dosage; Lactones - therapeutic use; Lipase - antagonists & inhibitors; Lipid Metabolism - drug effects; Lipids; Lipids - blood; Liver - metabolism; Low fat diet; Magnetic resonance imaging; Magnetic resonance spectroscopy; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Middle Aged; Nonprescription Drugs - administration & dosage; Nonprescription Drugs - therapeutic use; Nutrient deficiency; Obesity; Obesity, Abdominal - blood; Obesity, Abdominal - diet therapy; Obesity, Abdominal - drug therapy; Obesity, Abdominal - pathology; original-article; Orlistat; Overweight - blood; Overweight - diet therapy; Overweight - drug therapy; Overweight - pathology; Public Health; Risk analysis; Risk factors; Spectroscopy; Spectrum analysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight control; Weight loss; Weight Loss - drug effects; Young Adult
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2011.108

Background/Objectives: It is well established that combining a reduced calorie, low-fat diet with the lipase inhibitor orlistat results in significantly greater weight loss than placebo plus diet. This weight loss is accompanied by changes in adipose tissue (AT) distribution. As 60 mg orlistat is now available as an over-the-counter medication, the primary objective of this study was to determine whether 60 mg orlistat is effective as a weight loss option in a free-living community population with minimal professional input. Methods: AT and ectopic lipid content were measured using magnetic resonance imaging and 1 H MR spectroscopy, respectively, in 27 subjects following 3 months treatment with orlistat 60 mg and a reduced calorie, low-fat diet. Results: Significant reductions in intra-abdominal AT (−10.6%, P =0.023), subcutaneous (−11.7% P