Depression with melancholic features is associated with higher long-term risk for dementia

Abstract Background Depression has been reported to increase the risk of subsequently developing dementia, but the nature of this relation remains to be elucidated. Depression can be a prodrome/manifestation of dementia or an early risk factor, and the effect may differ according to depression subty...

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Bibliographic Details
Published in:Journal of affective disorders 2016-09, Vol.202, p.220-229
Main Authors: Simões do Couto, Frederico, Lunet, Nuno, Ginó, Sandra, Chester, Catarina, Freitas, Vanda, Maruta, Carolina, Figueira, Maria Luísa, de Mendonça, Alexandre
Format: Article
Language:English
Subjects:
Aged
Cohort Studies
Dementia
Dementia - diagnosis
Dementia - psychology
Depression
Depression - diagnosis
Depression - psychology
Depressive Disorder - diagnosis
Depressive Disorder - psychology
Female
Humans
Hypothalamus-Hypophysis-adrenal axis
Male
Melancholia
Middle Aged
Psychiatry
Retrospective Studies
Risk factor
Risk Factors
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Summary:Abstract Background Depression has been reported to increase the risk of subsequently developing dementia, but the nature of this relation remains to be elucidated. Depression can be a prodrome/manifestation of dementia or an early risk factor, and the effect may differ according to depression subtypes. Our aim was to study the association between early-onset depression and different depression subtypes, and the later occurrence of dementia. Methods We conducted a cohort study including 322 subjects with depression, recruited between 1977 and 1984. A comparison cohort (non-exposed) was recruited retrospectively, to include 322 subjects admitted at the same hospital for routine surgery (appendicectomy or cholecystectomy), at the same period as the depressed cohort. Subjects were contacted again between 2009 and 2014, to assess their dementia status. We computed the risk for dementia in subjects with early onset depression and quantified the association between different depression subtypes (namely melancholic, anxious, and psychotic) and dementia. Results The odds of dementia were increased by 2.90 times (95% C.I. 1.61-5.21; p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2016.05.026