A novel microcrystalline tyrosine-adsorbed, mite-allergoid subcutaneous immunotherapy: 1-year follow-up report

A 1-year follow-up study comparing the safety and tolerability of the dosing schedules, satisfaction and effectiveness of a novel microcrystalline tyrosine-adsorbed mite ( )-allergoid subcutaneous immunotherapy (Acarovac Plus™) in 30 adult patients (18-65 years) with allergic rhinitis and/or asthma....

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Bibliographic Details
Published in:Immunotherapy 2016-10, Vol.8 (10), p.1169-1174
Main Authors: Roger, Albert, Depreux, Nathalie, Jurgens, Yanina, Serra, Aina T, Heath, Matthew D, Garcia, Gloria, Skinner, Murray A
Format: Article
Language:English
Subjects:
Acarovac Plus
allergen
Allergic rhinitis
Allergies
allergoid
Asthma
cluster
conventional
Dermatophagoides
Drug dosages
Dust
Immunoglobulin E
Immunoglobulin G
Immunological tolerance
Immunology
Immunotherapy
Interleukin 10
nasal challenge test
Patients
Questionnaires
Respiration
Studies
subcutaneous
Tyrosine
Vaccines
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Summary:A 1-year follow-up study comparing the safety and tolerability of the dosing schedules, satisfaction and effectiveness of a novel microcrystalline tyrosine-adsorbed mite ( )-allergoid subcutaneous immunotherapy (Acarovac Plus™) in 30 adult patients (18-65 years) with allergic rhinitis and/or asthma. The effectiveness of the product was assessed by nasal provocation test measuring peak nasal inspiratory flow/symptoms, immunologic changes (IgE, IgG4 and IL-10) and Treatment Satisfaction Questionnaire for Medication. No adverse events were reported during dosing schedules. Significant decreases in symptom scores and drop of peak nasal inspiratory flow in follow-up visits (4 weeks and 1 year) were recorded. Significant increases in IgG4-specific antibody titers and IL-10 were exhibited. Significant decreases in clinical symptoms and immunological parameters were observed, accompanying a high level of patient satisfaction and tolerance.
ISSN:1750-743X
1750-7448
DOI:10.2217/imt-2016-0068