Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study

ABSTRACT Background: Elevated serum calcium has been associated with a variety of metabolic abnormalities and may be associated with a greater risk of diabetes. Objective: The purpose of this study was to test the hypothesis that serum calcium concentration is positively and independently associated...

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Published in:The American journal of clinical nutrition 2016-10, Vol.104 (4), p.1023-1029
Main Authors: Rooney, Mary R, Pankow, James S, Sibley, Shalamar D, Selvin, Elizabeth, Reis, Jared P, Michos, Erin D, Lutsey, Pamela L
Format: Article
Language:English
Subjects:
Atherosclerosis
Atherosclerosis - etiology
Black People
Calcium
Calcium - blood
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - genetics
Female
Genotype
Humans
Incidence
Male
Middle Aged
Nutritional Status - genetics
Pathogenesis
Polymorphism
Polymorphism, Single Nucleotide
Proportional Hazards Models
Receptors, Calcium-Sensing - genetics
Risk Factors
White People
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Summary:ABSTRACT Background: Elevated serum calcium has been associated with a variety of metabolic abnormalities and may be associated with a greater risk of diabetes. Objective: The purpose of this study was to test the hypothesis that serum calcium concentration is positively and independently associated with the incidence of diabetes and to evaluate the association of calcium-sensing receptor (CaSR) gene single nucleotide polymorphism (SNP) rs1801725 with incident diabetes. Design: Atherosclerosis Risk in Communities study participants free of diabetes at baseline (n = 12,800; mean age: 53.9 y; 22.6% black) were studied for incident diabetes. Serum calcium was measured at baseline and corrected for serum albumin. Diabetes was defined by use of glucose concentrations, self-report, or medication use. Cox proportional hazards regression was used. Results: During a mean 8.8 y of follow-up, 1516 cases of diabetes were reported. Participants in the highest compared with lowest calcium quintile were at greater risk of incident diabetes after adjustment for demographic and lifestyle factors [HR (95% CI): 1.34 (1.14, 1.57); P-trend across quintiles
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.115.130021