Knowledge Obtained from an Elderly Case of Japanese Encephalitis

The nationwide introduction of a Japanese encephalitis (JE) vaccine has contributed to a reduction in the annual infection rate of JE in Japan. However, the current neutralizing antibody prevalence ratio in Japan is approximately 20% in children 3-4 years of age and in people in their forties and fi...

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Bibliographic Details
Published in:Internal Medicine 2016/09/01, Vol.55(17), pp.2487-2490
Main Authors: Itoh, Kyoko, Iwamoto, Kazuhide, Satoh, Yu, Fujita, Tomoaki, Takahashi, Kenta, Katano, Harutaka, Hasegawa, Hideki, Takasaki, Tomohiko, Tando, So, Fushiki, Shinji
Format: Article
Language:English
Subjects:
Aged
Antibodies, Viral - immunology
Biopsy
Encephalitis, Japanese - diagnosis
Humans
Japan
Japanese encephalitis
magnetic resonance imaging
Male
multi-virus real-time PCR
neutralizing antibody
pathology
Real-Time Polymerase Chain Reaction
vaccination
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Summary:The nationwide introduction of a Japanese encephalitis (JE) vaccine has contributed to a reduction in the annual infection rate of JE in Japan. However, the current neutralizing antibody prevalence ratio in Japan is approximately 20% in children 3-4 years of age and in people in their forties and fifties. We herein report a man with JE who was definitively diagnosed by multi-virus real-time polymerase chain reaction employing biopsied brain tissue and serological examinations. JE should be kept in mind when a patient has severe encephalitis of unknown etiology. In order to protect the susceptible population from JE, vaccination is recommended, especially for children and middle-aged people.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.55.6646