The road to restoring neural circuits for the treatment of Alzheimer's disease

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 2016-11, Vol.539 (7628), p.187-196
Main Authors: Canter, Rebecca G., Penney, Jay, Tsai, Li-Huei
Format: Article
Language:English
Subjects:
631/378
692/699
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Alzheimer Disease - therapy
Alzheimer's disease
Amyloid beta-Peptides - biosynthesis
Amyloid beta-Peptides - metabolism
Animal cognition
Animals
Brain
Care and treatment
Clinical trials
Cognition - drug effects
Cognitive ability
Disease Progression
Genes
Genetic engineering
Health aspects
Humanities and Social Sciences
Humans
Memory
multidisciplinary
Mutation
Neural circuitry
Neural Pathways - drug effects
Neural Pathways - pathology
Neurodegeneration
Peptides
Proteins
review-article
Science
Synapses - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. Instead, a broad outlook on neural-circuit-damaging processes may yield insights into new therapeutic strategies for curing memory loss in the disease.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature20412