High dose oral ganciclovir treatment for cytomegalovirus retinitis

• Published in: Journal of clinical virology 2002-02, Vol.24 (1), p.67-77
• Main Authors: Lalezari, Jacob P., Friedberg, Dorothy N., Bissett, Jack, Giordano, Michael F., Hardy, W.David, Drew, W.Lawrence, Hubbard, Larry D., Buhles, William C., Stempien, Mary Jean, Georgiou, Panos, Jung, Donald T., Robinson, Charles A.
• Format: Article
• Language: English
• Subjects: Acquired Immunodeficiency Syndrome - complications; Administration, Oral; Adult; AIDS-Related Opportunistic Infections - complications; AIDS-Related Opportunistic Infections - drug therapy; Antiviral Agents - therapeutic use; Biological and medical sciences; Cytomegalovirus; Cytomegalovirus Retinitis - complications; Cytomegalovirus Retinitis - drug therapy; Cytomegalovirus Retinitis - metabolism; Disease Progression; Female; Fundamental and applied biological sciences. Psychology; Ganciclovir - adverse effects; Ganciclovir - therapeutic use; Humans; Injections, Intravenous; Male; Microbiology; Oral ganciclovir; Pharmacodynamics; Pharmacokinetics; Retinitis; Survival Analysis; Treatment Outcome; Visual Acuity
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/S1386-6532(01)00229-3

Background: The oral formulation of ganciclovir is approved at a dose of 3.0 g/day for maintenance treatment of cytomegalovirus (CMV) retinitis following an initial induction course of intravenous (IV) anti-CMV therapy. Median time to progression of CMV retinitis is 12–20 days shorter with oral compared to IV ganciclovir maintenance, likely due to the limited oral bioavailability of ganciclovir. Objectives: We hypothesized that higher systemic drug exposures associated with increased doses of oral ganciclovir would be associated with increased efficacy. Study design: Maintenance treatment of CMV retinitis with higher than standard doses of oral ganciclovir (>3.0 g/day) was studied in 281 AIDS patients with previously treated, stable retinitis randomized to 3.0, 4.5 or 6.0 g/day oral, or 5 m/kg/day IV ganciclovir. Graders unaware of treatment assignments determined retinitis progression using fundus photographs. Vision, other ophthalmic measures and safety were assessed open-label. Results: Median days to photographic progression were 41, 50, 57 and 70, respectively ( P=0.052; 3.0 g vs. IV). Hazard ratios for progression relative to IV were 1.66, 1.28 and 1.19 ( P=0.016 for 3.0 g). NONMEM-modeled estimates of average serum ganciclovir concentration area under the curve (AUC 0–24) correlated best with time to progression ( P=0.0019). Six grams per day oral ganciclovir was most similar in efficacy to IV, although broad confidence intervals prevented a conclusive comparison. Patients receiving oral ganciclovir had a lower frequency of sepsis and IV catheter events. Conclusions: This study suggests that the efficacy of ganciclovir for the maintenance treatment of CMV retinitis improves with increasing total drug exposure (measured as average serum concentration AUC 0–24). All four regimens of ganciclovir were reasonably well tolerated, with safety profiles similar to what has been reported in prior work.