Management of dry mouth: assessment of oral symptoms after use of a polysaccharide-based oral rinse

Objective Salivary dysfunction is associated with a range of oral/dental issues, and management of oral symptoms may improve oral function and overall quality of life. The purpose of this pilot study was to evaluate oral symptoms and function in a xerostomic population after use of a proprietary top...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2017-01, Vol.123 (1), p.76-83
Main Authors: Epstein, Joel B., DMD, MSD, FRCD(C), FDS RCS(Ed), Diplomate ABOM, Villines, Dana C., MA, Singh, Mabi, DMD MS, Papas, Athena, DMD, PhD
Format: Article
Language:English
Subjects:
Chitosan - analogs & derivatives
Chitosan - pharmacology
Dentistry
Female
Humans
Male
Middle Aged
Mouthwashes
Pilot Projects
Surgery
Treatment Outcome
Xerostomia - prevention & control
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Summary:Objective Salivary dysfunction is associated with a range of oral/dental issues, and management of oral symptoms may improve oral function and overall quality of life. The purpose of this pilot study was to evaluate oral symptoms and function in a xerostomic population after use of a proprietary topical for dry mouth, Moisyn (Synedgen Inc., Claremont, CA), which is a polysaccharide-based product. Study Design A pre- and post-test survey was completed by 57 patients with xerostomia. Patients rated their common oral symptoms, based on the Vanderbilt Head and Neck Symptom Survey, before and after 1-week use of Moisyn rinse and spray. Saliva production under resting and chewing stimulation was also assessed. Results Most patients reported relief from dry mouth symptoms and thick saliva (81.7% and 76.0%, respectively) for more than 30 minutes after product use. Statistically significant reductions were found in 15 of 33 oral symptoms. Symptom improvement ranged from 10.7% to 28.4% for thick saliva, 8.4% to 30.6% for pain, 5.5% to 30.4% for dry mouth, and 12% to 21.3% for taste/diet change. Whole unstimulated/resting saliva improved by 100%, and whole stimulated saliva improved by 23.8%. Conclusions These findings suggest that the product has utility in symptom control in patients with xerostomia and may lead to an increase in saliva production.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2016.09.008